| Reaction Details |
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 | Report a problem with these data |
| Target | Cytochrome P450 2D4 |
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| Ligand | BDBM50122613 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_51712 (CHEMBL665727) |
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| IC50 | 747000±n/a nM |
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| Citation |  Venhorst, J; ter Laak, AM; Commandeur, JN; Funae, Y; Hiroi, T; Vermeulen, NP Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities. J Med Chem46:74-86 (2002) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cytochrome P450 2D4 |
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| Name: | Cytochrome P450 2D4 |
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| Synonyms: | CP2D4_RAT | CYPIID4 | Cyp2d-18 | Cyp2d-4 | Cyp2d18 | Cyp2d4 | Cytochrome P450 2D18 | Cytochrome P450 2D4 | Cytochrome P450-CMF3 | Cytochrome P450-DB4 | Debrisoquine 4-hydroxylase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 56689.73 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_1280215 |
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| Residue: | 500 |
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| Sequence: | MRMPTGSELWPIAIFTIIFLLLVDLMHRRQRWTSRYPPGPVPWPVLGNLLQIDFQNMPAG
FQKLRCRFGDLFSLQLAFESVVVLNGLPALREALVKYSEDTADRPPLHFNDQSGFGPRSQ
GVVLARYGPAWRQQRRFSVSTFRHFGLGKKSLEQWVTEEARCLCAAFADHSGFPFSPNTL
LDKAVCNVIASLLFACRFEYNDPRFIRLLDLLKDTLEEESGFLPMLLNVFPMLLHIPGLL
GKVFSGKKAFVAMLDELLTEHKVTWDPAQPPRDLTDAFLAEVEKAKGNPESSFNDENLRV
VVADLFMAGMVTTSTTLTWALLFMILRPDVQCRVQQEIDEVIGQVRRPEMADQARMPFTN
AVIHEVQRFADILPLGVPHKTSRDIEVQGFLIPKGTTLIINLSSVLKDETVWEKPLRFHP
EHFLDAQGNFVKHEAFMPFSAGRRACLGEPLARMELFLFFTCLLQRFSFSVPAGQPRPSN
YGVFGALTTPRPYQLCASPR
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| BDBM50122613 |
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| n/a |
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| Name | BDBM50122613 |
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| Synonyms: | 3,4-dihydroisoquinoline-2(1H)-carboximidamide | CHEMBL169901 | Debrisochinum | Debrisoquin | Isocaramidine |
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| Type | Small organic molecule |
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| Emp. Form. | C10H13N3 |
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| Mol. Mass. | 175.2303 |
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| SMILES | NC(=N)N1CCc2ccccc2C1 |
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| Structure | 
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