| Reaction Details |
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 | Report a problem with these data |
| Target | B1 bradykinin receptor |
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| Ligand | BDBM50127449 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_39982 (CHEMBL653556) |
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| Ki | 141±n/a nM |
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| Citation |  Wood, MR; Kim, JJ; Han, W; Dorsey, BD; Homnick, CF; DiPardo, RM; Kuduk, SD; MacNeil, T; Murphy, KL; Lis, EV; Ransom, RW; Stump, GL; Lynch, JJ; O'Malley, SS; Miller, PJ; Chen, TB; Harrell, CM; Chang, RS; Sandhu, P; Ellis, JD; Bondiskey, PJ; Pettibone, DJ; Freidinger, RM; Bock, MG Benzodiazepines as potent and selective bradykinin B1 antagonists. J Med Chem46:1803-6 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| B1 bradykinin receptor |
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| Name: | B1 bradykinin receptor |
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| Synonyms: | B1 BRADYKININ | B1 bradykinin receptor | B1R | BDKRB1 | BK-1 receptor | BKRB1_HUMAN | BRADYB1 | Bradykinin B1 receptor |
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| Type: | Enzyme |
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| Mol. Mass.: | 40508.87 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P46663 |
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| Residue: | 353 |
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| Sequence: | MASSWPPLELQSSNQSQLFPQNATACDNAPEAWDLLHRVLPTFIISICFFGLLGNLFVLL
VFLLPRRQLNVAEIYLANLAASDLVFVLGLPFWAENIWNQFNWPFGALLCRVINGVIKAN
LFISIFLVVAISQDRYRVLVHPMASRRQQRRRQARVTCVLIWVVGGLLSIPTFLLRSIQA
VPDLNITACILLLPHEAWHFARIVELNILGFLLPLAAIVFFNYHILASLRTREEVSRTRC
GGRKDSKTTALILTLVVAFLVCWAPYHFFAFLEFLFQVQAVRGCFWEDFIDLGLQLANFF
AFTNSSLNPVIYVFVGRLFRTKVWELYKQCTPKSLAPISSSHRKEIFQLFWRN
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| BDBM50127449 |
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| n/a |
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| Name | BDBM50127449 |
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| Synonyms: | CHEMBL30525 | iN-(4-[1,4']Bipiperidinyl-1'-yl-phenyl)-4-(5-cyclohexyl-2-oxo-2,3-dihydro-benzo[e][1,4]diazepin-1-yl)-butyramide |
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| Type | Small organic molecule |
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| Emp. Form. | C35H47N5O2 |
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| Mol. Mass. | 569.78 |
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| SMILES | O=C(CCCN1c2ccccc2C(=NCC1=O)C1CCCCC1)Nc1ccc(cc1)N1CCC(CC1)N1CCCCC1 |c:13| |
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| Structure | 
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