| Reaction Details |
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 | Report a problem with these data |
| Target | DNA polymerase III PolC-type |
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| Ligand | BDBM50129757 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_50803 (CHEMBL659771) |
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| Ki | 25±n/a nM |
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| Citation |  Zhi, C; Long, ZY; Gambino, J; Xu, WC; Brown, NC; Barnes, M; Butler, M; LaMarr, W; Wright, GE Synthesis of substituted 6-anilinouracils and their inhibition of DNA polymerase IIIC and Gram-positive bacterial growth. J Med Chem46:2731-9 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| DNA polymerase III PolC-type |
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| Name: | DNA polymerase III PolC-type |
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| Synonyms: | DNA polymerase III | DNA polymerase IIIC | DNA-directed DNA polymerase | DPO3_BACSU | PolIII | dnaF | mutI | polC |
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| Type: | Enzyme |
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| Mol. Mass.: | 162625.67 |
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| Organism: | Bacillus subtilis |
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| Description: | Enzyme was purified from recombinant strains. |
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| Residue: | 1437 |
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| Sequence: | MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASKSWHFHFQFKSLLPFQI
YDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCIEELQGISPPIISLLNQQK
PKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPDLQLDAEIFVSEQEVQKFREQ
KLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQIKDNEEIRTLDSIMDEERRITV
QGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFAREKEDAALMKSLKKGMWVKARGSI
QNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKRVELHLHSPMSQMDAVTGIGKLVEQAK
KWGHEAIALTDHAVVQSFPDAYSAAKKHGIKMIYGMEANLVDDGVPIAYNAAHRLLEEET
YVVFDVETTGLSAVYDTIIELAAVKVKGGEIIDKFEAFANPHRPLSATIIELTGITDDML
QDAPDVVDVIRDFREWIGDDILVAHNASFDMGFLNVAYKKLLEVEKAKNPVIDTLELGRF
LYPEFKNHRLNTLCKKFDIELTQHHRAIYDTEATAYLLLKMLKDAAEKGIQYHDELNENM
GQSNAYQRSRPYHATLLAVNSTGLKNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIG
SACDRGEVFEGMMQKSPEEVEDIASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANI
TKLGEKLNKPVVATGNVHYLNDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEA
FSFLGEEKAKEIVVTNTQKVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGE
ELPEIVEARIEKELKSIIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEI
TEVNPLPPHYVCPECQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFK
GDKVPDIDLNFSGEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLH
MRGAEIDRLVQGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDF
HSIHDNLLKLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIG
CKTGTLGIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELS
EVIGCRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKI
KYMFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED
INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNSIP
GLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSLF
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| BDBM50129757 |
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| n/a |
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| Name | BDBM50129757 |
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| Synonyms: | 3-{4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-butyl}-6-(3-ethyl-4-methyl-phenylamino)-1H-pyrimidine-2,4-dione | CHEMBL91225 |
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| Type | Small organic molecule |
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| Emp. Form. | C28H35ClN4O3 |
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| Mol. Mass. | 511.055 |
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| SMILES | CCc1cc(Nc2cc(=O)n(CCCCN3CCC(O)(CC3)c3ccc(Cl)cc3)c(=O)[nH]2)ccc1C |
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| Structure | 
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