| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydrofolate reductase |
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| Ligand | BDBM50092656 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_55110 (CHEMBL665437) |
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| IC50 | 120±n/a nM |
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| Citation |  Graffner-Nordberg, M; Fyfe, M; Brattsand, R; Mellgård, B; Hallberg, A Design and synthesis of dihydrofolate reductase inhibitors encompassing a bridging ester group. Evaluation in a mouse colitis model. J Med Chem46:3455-62 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Dihydrofolate reductase |
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| Name: | Dihydrofolate reductase |
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| Synonyms: | DYR_RAT | Dhfr | Dihydrofolate reductase (DHFR) | Dihydrofolate reductase; P. carinii vs rat | Tetrahydrofolate dehydrogenase |
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| Type: | Enzyme |
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| Mol. Mass.: | 21638.84 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 187 |
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| Sequence: | MVRPLNCIVAVSQNMGIGKNGDLPWPLLRNEFKYFQRMTTTSSVEGKQNLVIMGRKTWFS
IPEKNRPLKDRINIVLSRELKEPPQGAHFLAKSLDDALKLIEQPELASKVDMVWVVGGSS
VYQEAMNQPGHLRLFVTRIMQEFESDTFFPEIDLEKYKLLPEYPGVLSEIQEEKGIKYKF
EVYEKKD
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|
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| BDBM50092656 |
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| n/a |
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| Name | BDBM50092656 |
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| Synonyms: | 2-[4-(2,4-Diamino-pteridin-6-ylmethoxycarbonyl)-benzoylamino]-pentanedioic acid | CHEMBL327066 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19N7O7 |
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| Mol. Mass. | 469.4076 |
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| SMILES | Nc1nc(N)c2nc(COC(=O)c3ccc(cc3)C(=O)N[C@@H](CCC(O)=O)C(O)=O)cnc2n1 |
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| Structure | 
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