| Reaction Details |
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 | Report a problem with these data |
| Target | 5-hydroxytryptamine receptor 1A |
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| Ligand | BDBM22417 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_820 (CHEMBL615820) |
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| IC50 | >1000±n/a nM |
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| Citation |  Orjales, A; Mosquera, R; Toledo, A; Pumar, MC; García, N; Cortizo, L; Labeaga, L; Innerárity, A Syntheses and binding studies of new [(aryl)(aryloxy)methyl]piperidine derivatives and related compounds as potential antidepressant drugs with high affinity for serotonin (5-HT) and norepinephrine (NE) transporters. J Med Chem46:5512-32 (2003) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 5-hydroxytryptamine receptor 1A |
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| Name: | 5-hydroxytryptamine receptor 1A |
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| Synonyms: | 5-HT-1A | 5-HT1 | 5-HT1A | 5-Hydroxytryptamine receptor 1A (5-HT1A) | 5-hydroxytryptamine receptor 1A (5HT1A) | 5HT1A_RAT | 5ht1a | G-21 | Htr1a | Serotonin 1 (5-HT1) receptor | Serotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1 | Serotonin receptor 1A |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 46445.29 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Binding assays were performed using rat hippocampal membranes. |
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| Residue: | 422 |
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| Sequence: | MDVFSFGQGNNTTASQEPFGTGGNVTSISDVTFSYQVITSLLLGTLIFCAVLGNACVVAA
IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVLNKWTLGQVTCDLFIALDVLCC
TSSILHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPMLGWRTPED
RSDPDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVRKVEKKGAGT
SLGTSSAPPPKKSLNGQPGSGDWRRCAENRAVGTPCTNGAVRQGDDEATLEVIEVHRVGN
SKEHLPLPSESGSNSYAPACLERKNERNAEAKRKMALARERKTVKTLGIIMGTFILCWLP
FFIVALVLPFCESSCHMPALLGAIINWLGYSNSLLNPVIYAYFNKDFQNAFKKIIKCKFC
RR
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| BDBM22417 |
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| n/a |
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| Name | BDBM22417 |
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| Synonyms: | 3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-amine | CHEMBL295467 | LY 135252 | LY 94939 | LY135252 | LY139602 | Nisoxetine | Nisoxetine Inhibitor | US9944618, Compound ID No. 177 | [3-(2-methoxyphenoxy)-3-phenylpropyl](methyl)amine | [3H]Nisoxetine |
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| Type | radiolabeled ligand |
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| Emp. Form. | C17H21NO2 |
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| Mol. Mass. | 271.3541 |
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| SMILES | CNCCC(Oc1ccccc1OC)c1ccccc1 |
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| Structure | 
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