| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Caspase-3 |
|---|
| Ligand | BDBM50149205 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_46677 (CHEMBL658635) |
|---|
| Ki | 2800±n/a nM |
|---|
| Citation |  Erlanson, DA; McDowell, RS; O'Brien, T Fragment-based drug discovery. J Med Chem47:3463-82 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Caspase-3 |
|---|
| Name: | Caspase-3 |
|---|
| Synonyms: | Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein |
|---|
| Type: | Hydrolase; heterotetramer of two heterodimers |
|---|
| Mol. Mass.: | 31607.55 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | n/a |
|---|
| Residue: | 277 |
|---|
| Sequence: | MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTG
MTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLS
HGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDD
DMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVN
RKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
|
|
|
|---|
| BDBM50149205 |
|---|
| n/a |
|---|
| Name | BDBM50149205 |
|---|
| Synonyms: | 5-[5-((R)-1-Carboxy-2-oxo-ethylcarbamoyl)-pentylsulfamoyl]-2-hydroxy-benzoic acid | CHEMBL117572 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H20N2O9S |
|---|
| Mol. Mass. | 416.403 |
|---|
| SMILES | OC(=O)[C@H](NC(=O)CCCCCNS(=O)(=O)c1ccc(O)c(c1)C(O)=O)C=O |
|---|
| Structure | 
|
|---|
Search and Browse
