| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A1 |
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| Ligand | BDBM50149363 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_29111 (CHEMBL638723) |
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| Ki | 61±n/a nM |
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| Citation |  Colotta, V; Catarzi, D; Varano, F; Calabri, FR; Lenzi, O; Filacchioni, G; Martini, C; Trincavelli, L; Deflorian, F; Moro, S 1,2,4-triazolo[4,3-a]quinoxalin-1-one moiety as an attractive scaffold to develop new potent and selective human A3 adenosine receptor antagonists: synthesis, pharmacological, and ligand-receptor modeling studies. J Med Chem47:3580-90 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A1 |
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| Name: | Adenosine receptor A1 |
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| Synonyms: | AA1R_BOVIN | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | ADORA1 | Adenosine A1 receptor |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 36602.99 |
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| Organism: | BOVINE |
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| Description: | ADENOSINE 0 BOVINE::P28190 |
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| Residue: | 326 |
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| Sequence: | MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPRTYFHTCLKVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVT
PRRAVVAITGCWILSFVVGLTPMFGWNNLSAVERDWLANGSVGEPVIECQFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYMEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHMPRILIYIAIFLSHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPVDEDAPAERPDD
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| BDBM50149363 |
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| n/a |
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| Name | BDBM50149363 |
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| Synonyms: | 4,6-Diamino-2-(4-hydroxy-phenyl)-2H-[1,2,4]triazolo[4,3-a]quinoxalin-1-one | CHEMBL331946 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H12N6O2 |
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| Mol. Mass. | 308.2948 |
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| SMILES | Nc1nc2c(N)cccc2n2c1nn(-c1ccc(O)cc1)c2=O |
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| Structure | 
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