| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A2b |
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| Ligand | BDBM50150076 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_31079 (CHEMBL640610) |
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| EC50 | 9±n/a nM |
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| Citation |  Beukers, MW; Chang, LC; von Frijtag Drabbe Künzel, JK; Mulder-Krieger, T; Spanjersberg, RF; Brussee, J; IJzerman, AP New, non-adenosine, high-potency agonists for the human adenosine A2B receptor with an improved selectivity profile compared to the reference agonist N-ethylcarboxamidoadenosine. J Med Chem47:3707-9 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A2b |
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| Name: | Adenosine receptor A2b |
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| Synonyms: | AA2BR_HUMAN | ADENOSINE A2B | ADORA2B | Adenosine receptor A2B (A2B) | Adenosine receptors A2b | Adenosine receptors; A2a & A2b |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 36341.22 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 332 |
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| Sequence: | MLLETQDALYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGLFA
IPFAITISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKSLVTGT
RARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFENVVPMS
YMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKSLAMIV
GIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNRDFRYT
FHKIISRYLLCQADVKSGNGQAGVQPALGVGL
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| BDBM50150076 |
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| n/a |
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| Name | BDBM50150076 |
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| Synonyms: | 2-((1H-imidazol-2-yl)methylthio)-6-amino-4-(4-methoxyphenyl)pyridine-3,5-dicarbonitrile | 2-Amino-6-(1H-imidazol-2-ylmethylsulfanyl)-4-(4-methoxy-phenyl)-pyridine-3,5-dicarbonitrile | CHEMBL122396 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H14N6OS |
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| Mol. Mass. | 362.408 |
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| SMILES | COc1ccc(cc1)-c1c(C#N)c(N)nc(SCc2ncc[nH]2)c1C#N |
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| Structure | 
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