| Reaction Details |
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 | Report a problem with these data |
| Target | Adenylate cyclase type 5 |
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| Ligand | BDBM50370376 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_31714 (CHEMBL645374) |
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| IC50 | 4600±n/a nM |
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| Citation |  Ye, S; Rezende, MM; Deng, WP; Herbert, B; Daly, JW; Johnson, RA; Kirk, KL Synthesis of 2',5'-dideoxy-2-fluoroadenosine and 2',5'-dideoxy-2,5'-difluoroadenosine: potent P-site inhibitors of adenylyl cyclase. J Med Chem47:1207-13 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenylate cyclase type 5 |
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| Name: | Adenylate cyclase type 5 |
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| Synonyms: | ADCY5_RAT | ATP pyrophosphate-lyase 5 | Adcy5 | Adenylate cyclase type 5 | Adenylate cyclase type IX | Adenylate cyclase type V | Adenylyl cyclase 5 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 139188.88 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_31725 |
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| Residue: | 1262 |
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| Sequence: | MSGSKSVSPPGYAAQTAASPAPRGGPEHRAAWGEADSRANGYPHAPGGSTRGSTKRSGGA
VTPQQQQRLASRWRGGDDDEDPPLSGDDPLVGGFGFSFRSKSAWQERGGDDGGRGSRRQR
RGAAGGGSTRAPPAGGSGSSAAAAAAAGGTEVRPRSVEVGLEERRGKGRAAEELEPGTGT
VEDGDGSEDGGSSVASGSGTGTVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQ
SSLTMLMAVLVLVCLVMLAFHAARPPLQVVYLAVLAAAVGVILIMAVLCNRAAFHQDHMG
LACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSA
LHLAISLHTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARL
HSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFT
SLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVE
MGMDMIEAISSVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGG
KAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKM
NRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEF
LGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQ
ITIVPHSLFMLSFYLSCFLLLALVVFISVIYACVKLFPTPLQTLSRKIVRSKKNSTLVGV
FTITLVFLSAFVNMFMCNSKNLVGCLAEEHNITVNQVNACHVMESAFNYSLGDEQGFCGS
PQSNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNAD
LLVTANAIDFSNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWK
LQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIAN
FSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDST
YDKAGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIW
GNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPP
LS
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| BDBM50370376 |
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| n/a |
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| Name | BDBM50370376 |
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| Synonyms: | CHEMBL1229920 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H12FN5O3 |
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| Mol. Mass. | 269.2324 |
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| SMILES | Nc1nc(F)nc2n(cnc12)[C@H]1C[C@H](O)[C@@H](CO)O1 |r| |
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| Structure | 
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