| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Adenylate cyclase type 5 |
|---|
| Ligand | BDBM50008363 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_31714 (CHEMBL645374) |
|---|
| IC50 | >100000±n/a nM |
|---|
| Citation |  Ye, S; Rezende, MM; Deng, WP; Herbert, B; Daly, JW; Johnson, RA; Kirk, KL Synthesis of 2',5'-dideoxy-2-fluoroadenosine and 2',5'-dideoxy-2,5'-difluoroadenosine: potent P-site inhibitors of adenylyl cyclase. J Med Chem47:1207-13 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Adenylate cyclase type 5 |
|---|
| Name: | Adenylate cyclase type 5 |
|---|
| Synonyms: | ADCY5_RAT | ATP pyrophosphate-lyase 5 | Adcy5 | Adenylate cyclase type 5 | Adenylate cyclase type IX | Adenylate cyclase type V | Adenylyl cyclase 5 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 139188.88 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_31725 |
|---|
| Residue: | 1262 |
|---|
| Sequence: | MSGSKSVSPPGYAAQTAASPAPRGGPEHRAAWGEADSRANGYPHAPGGSTRGSTKRSGGA
VTPQQQQRLASRWRGGDDDEDPPLSGDDPLVGGFGFSFRSKSAWQERGGDDGGRGSRRQR
RGAAGGGSTRAPPAGGSGSSAAAAAAAGGTEVRPRSVEVGLEERRGKGRAAEELEPGTGT
VEDGDGSEDGGSSVASGSGTGTVLSLGACCLALLQIFRSKKFPSDKLERLYQRYFFRLNQ
SSLTMLMAVLVLVCLVMLAFHAARPPLQVVYLAVLAAAVGVILIMAVLCNRAAFHQDHMG
LACYALIAVVLAVQVVGLLLPQPRSASEGIWWTVFFIYTIYTLLPVRMRAAVLSGVLLSA
LHLAISLHTNAQDQFLLKQLVSNVLIFSCTNIVGVCTHYPAEVSQRQAFQETRECIQARL
HSQRENQQQERLLLSVLPRHVAMEMKADINAKQEDMMFHKIYIQKHDNVSILFADIEGFT
SLASQCTAQELVMTLNELFARFDKLAAENHCLRIKILGDCYYCVSGLPEARADHAHCCVE
MGMDMIEAISSVREVTGVNVNMRVGIHSGRVHCGVLGLRKWQFDVWSNDVTLANHMEAGG
KAGRIHITKATLNYLNGDYEVEPGCGGERNAYLKEHSIETFLILRCTQKRKEEKAMIAKM
NRQRTNSIGHNPPHWGAERPFYNHLGGNQVSKEMKRMGFEDPKDKNAQESANPEDEVDEF
LGRAIDARSIDRLRSEHVRKFLLTFREPDLEKKYSKQVDDRFGAYVACASLVFLFICFVQ
ITIVPHSLFMLSFYLSCFLLLALVVFISVIYACVKLFPTPLQTLSRKIVRSKKNSTLVGV
FTITLVFLSAFVNMFMCNSKNLVGCLAEEHNITVNQVNACHVMESAFNYSLGDEQGFCGS
PQSNCNFPEYFTYSVLLSLLACSVFLQISCIGKLVLMLAIELIYVLIVEVPGVTLFDNAD
LLVTANAIDFSNNGTSQCPEHATKVALKVVTPIIISVFVLALYLHAQQVESTARLDFLWK
LQATEEKEEMEELQAYNRRLLHNILPKDVAAHFLARERRNDELYYQSCECVAVMFASIAN
FSEFYVELEANNEGVECLRLLNEIIADFDEIISEDRFRQLEKIKTIGSTYMAASGLNDST
YDKAGKTHIKALADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIW
GNTVNVASRMDSTGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPP
LS
|
|
|
|---|
| BDBM50008363 |
|---|
| n/a |
|---|
| Name | BDBM50008363 |
|---|
| Synonyms: | 5-(6-Amino-2-fluoro-purin-9-yl)-2-hydroxymethyl-tetrahydro-furan-3-ol | CHEMBL279654 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H12FN5O3 |
|---|
| Mol. Mass. | 269.2324 |
|---|
| SMILES | Nc1nc(F)nc2n(cnc12)C1CC(O)C(CO)O1 |
|---|
| Structure | 
|
|---|
Search and Browse
