Reaction Details |
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Target | Delta-type opioid receptor |
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Ligand | BDBM50143608 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_145190 (CHEMBL754435) |
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Ki | 1100±n/a nM |
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Citation | Zhang, A; Xiong, W; Hilbert, JE; DeVita, EK; Bidlack, JM; Neumeyer, JL 2-aminothiazole-derived opioids. Bioisosteric replacement of phenols. J Med Chem47:1886-8 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Delta-type opioid receptor |
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Name: | Delta-type opioid receptor |
Synonyms: | D-OR-1 | DOR-1 | Delta opioid receptor | Delta-type opioid receptor (Delta) | OPIATE Delta | OPRD | OPRD1 | OPRD_HUMAN | OPRK1 | opioid receptor, delta 1 |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 40382.98 |
Organism: | Homo sapiens (Human) |
Description: | Competition binding assays were carried out using membrane preparations from transfected HN9.10 cells that constitutively expressed the delta opioid receptor. |
Residue: | 372 |
Sequence: | MEPAPSAGAELQPPLFANASDAYPSACPSAGANASGPPGARSASSLALAIAITALYSAVC
AVGLLGNVLVMFGIVRYTKMKTATNIYIFNLALADALATSTLPFQSAKYLMETWPFGELL
CKAVLSIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPAKAKLINICIWVLASGVG
VPIMVMAVTRPRDGAVVCMLQFPSPSWYWDTVTKICVFLFAFVVPILIITVCYGLMLLRL
RSVRLLSGSKEKDRSLRRITRMVLVVVGAFVVCWAPIHIFVIVWTLVDIDRRDPLVVAAL
HLCIALGYANSSLNPVLYAFLDENFKRCFRQLCRKPCGRPDPSSFSRAREATARERVTAC
TPSDGPGGGAAA
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BDBM50143608 |
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n/a |
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Name | BDBM50143608 |
Synonyms: | 20-methyl-(1R,12R)-7-thia-5,20-diazapentacyclo[10.5.3.01,13.02,10.04,8]icosa-2(10),3,5,8-tetraen-6-amine | CHEMBL56360 |
Type | Small organic molecule |
Emp. Form. | C18H23N3S |
Mol. Mass. | 313.46 |
SMILES | CN1CC[C@]23CCCCC2[C@H]1Cc1cc2sc(N)nc2cc31 |TLB:8:9:21.12.11:1.3.2| |
Structure |
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