| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-2 receptor subunit alpha |
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| Ligand | BDBM50147979 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_89084 (CHEMBL878448) |
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| IC50 | 600±n/a nM |
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| Citation |  Raimundo, BC; Oslob, JD; Braisted, AC; Hyde, J; McDowell, RS; Randal, M; Waal, ND; Wilkinson, J; Yu, CH; Arkin, MR Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions. J Med Chem47:3111-30 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-2 receptor subunit alpha |
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| Name: | Interleukin-2 receptor subunit alpha |
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| Synonyms: | CD_antigen=CD25 | IL-2 receptor alpha subunit | IL-2-RA | IL2-RA | IL2RA_MOUSE | Il2r | Il2ra | Interleukin-2 receptor alpha chain | p55 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30733.96 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_89085 |
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| Residue: | 268 |
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| Sequence: | MEPRLLMLGFLSLTIVPSCRAELCLYDPPEVPNATFKALSYKNGTILNCECKRGFRRLKE
LVYMRCLGNSWSSNCQCTSNSHDKSRKQVTAQLEHQKEQQTTTDMQKPTQSMHQENLTGH
CREPPPWKHEDSKRIYHFVEGQSVHYECIPGYKALQRGPAISICKMKCGKTGWTQPQLTC
VDEREHHRFLASEESQGSRNSSPESETSCPITTTDFPQPTETTAMTETFVLTMEYKVAVA
SCLFLLISILLLSGLTWQHRWRKSRRTI
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| BDBM50147979 |
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| n/a |
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| Name | BDBM50147979 |
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| Synonyms: | CHEMBL106951 | {4-[2,3-Dichloro-4-(5-{1-[2-((R)-2-guanidino-4-methyl-1-oxo-pentylamino)-acetyl]-piperidin-4-yl}-1-methyl-1H-pyrazol-3-yl)-phenoxymethyl]-phenyl}-acetic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C33H41Cl2N7O5 |
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| Mol. Mass. | 686.629 |
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| SMILES | [#6]-[#6](-[#6])-[#6]-[#6@@H](\[#7]=[#6](/[#7])-[#7])-[#6](=O)-[#7]-[#6]-[#6](=O)-[#7]-1-[#6]-[#6]-[#6](-[#6]-[#6]-1)-c1cc(nn1-[#6])-c1ccc(-[#8]-[#6]-c2ccc(-[#6]-[#6](-[#8])=O)cc2)c(Cl)c1Cl |
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| Structure | 
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