| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-2 receptor subunit alpha |
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| Ligand | BDBM50147980 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_89085 (CHEMBL698595) |
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| IC50 | 720000±n/a nM |
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| Citation |  Raimundo, BC; Oslob, JD; Braisted, AC; Hyde, J; McDowell, RS; Randal, M; Waal, ND; Wilkinson, J; Yu, CH; Arkin, MR Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions. J Med Chem47:3111-30 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-2 receptor subunit alpha |
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| Name: | Interleukin-2 receptor subunit alpha |
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| Synonyms: | CD_antigen=CD25 | IL-2 receptor alpha subunit | IL-2-RA | IL2-RA | IL2RA_MOUSE | Il2r | Il2ra | Interleukin-2 receptor alpha chain | p55 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30733.96 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_89085 |
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| Residue: | 268 |
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| Sequence: | MEPRLLMLGFLSLTIVPSCRAELCLYDPPEVPNATFKALSYKNGTILNCECKRGFRRLKE
LVYMRCLGNSWSSNCQCTSNSHDKSRKQVTAQLEHQKEQQTTTDMQKPTQSMHQENLTGH
CREPPPWKHEDSKRIYHFVEGQSVHYECIPGYKALQRGPAISICKMKCGKTGWTQPQLTC
VDEREHHRFLASEESQGSRNSSPESETSCPITTTDFPQPTETTAMTETFVLTMEYKVAVA
SCLFLLISILLLSGLTWQHRWRKSRRTI
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| BDBM50147980 |
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| n/a |
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| Name | BDBM50147980 |
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| Synonyms: | (S)-2-{2-[(1-Carbamimidoyl-pyrrolidine-2-carbonyl)-amino]-acetylamino}-3-(4-phenylethynyl-phenyl)-propionic acid methyl ester | CHEMBL104086 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H29N5O4 |
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| Mol. Mass. | 475.5396 |
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| SMILES | COC(=O)[C@H](Cc1ccc(cc1)C#Cc1ccccc1)NC(=O)CNC(=O)[C@@H]1CCCN1C(N)=N |
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| Structure | 
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