Reaction Details |
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Target | Interleukin-2 receptor subunit alpha |
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Ligand | BDBM50147982 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_89084 (CHEMBL878448) |
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IC50 | 20000±n/a nM |
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Citation | Raimundo, BC; Oslob, JD; Braisted, AC; Hyde, J; McDowell, RS; Randal, M; Waal, ND; Wilkinson, J; Yu, CH; Arkin, MR Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions. J Med Chem47:3111-30 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Interleukin-2 receptor subunit alpha |
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Name: | Interleukin-2 receptor subunit alpha |
Synonyms: | CD_antigen=CD25 | IL-2 receptor alpha subunit | IL-2-RA | IL2-RA | IL2RA_MOUSE | Il2r | Il2ra | Interleukin-2 receptor alpha chain | p55 |
Type: | PROTEIN |
Mol. Mass.: | 30733.96 |
Organism: | Mus musculus |
Description: | ChEMBL_89085 |
Residue: | 268 |
Sequence: | MEPRLLMLGFLSLTIVPSCRAELCLYDPPEVPNATFKALSYKNGTILNCECKRGFRRLKE
LVYMRCLGNSWSSNCQCTSNSHDKSRKQVTAQLEHQKEQQTTTDMQKPTQSMHQENLTGH
CREPPPWKHEDSKRIYHFVEGQSVHYECIPGYKALQRGPAISICKMKCGKTGWTQPQLTC
VDEREHHRFLASEESQGSRNSSPESETSCPITTTDFPQPTETTAMTETFVLTMEYKVAVA
SCLFLLISILLLSGLTWQHRWRKSRRTI
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BDBM50147982 |
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n/a |
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Name | BDBM50147982 |
Synonyms: | 2-Cyclohexyl-N-(2-{4-[5-(2,3-dichloro-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethyl)-2-guanidino-acetamide | CHEMBL104746 |
Type | Small organic molecule |
Emp. Form. | C26H35Cl2N7O2 |
Mol. Mass. | 548.508 |
SMILES | [#6]-n1nc(cc1-[#6]-1-[#6]-[#6]-[#7](-[#6]-[#6]-1)-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@H](\[#7]=[#6](/[#7])-[#7])-[#6]-1-[#6]-[#6]-[#6]-[#6]-[#6]-1)-c1cccc(Cl)c1Cl |
Structure |
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