Reaction Details | |||
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Target | Interleukin-2 receptor subunit alpha | ||
Ligand | BDBM50147990 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | ChEMBL_89084 (CHEMBL878448) | ||
IC50 | 150000±n/a nM | ||
Citation | Raimundo, BC; Oslob, JD; Braisted, AC; Hyde, J; McDowell, RS; Randal, M; Waal, ND; Wilkinson, J; Yu, CH; Arkin, MR Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions. J Med Chem47:3111-30 (2004) [PubMed] Article | ||
More Info.: | Get all data from this article, Assay Method | ||
Interleukin-2 receptor subunit alpha | |||
Name: | Interleukin-2 receptor subunit alpha | ||
Synonyms: | CD_antigen=CD25 | IL-2 receptor alpha subunit | IL-2-RA | IL2-RA | IL2RA_MOUSE | Il2r | Il2ra | Interleukin-2 receptor alpha chain | p55 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 30733.96 | ||
Organism: | Mus musculus | ||
Description: | ChEMBL_89085 | ||
Residue: | 268 | ||
Sequence: |
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BDBM50147990 | |||
n/a | |||
Name | BDBM50147990 | ||
Synonyms: | 2-(R)-Cyclohexyl-2-guanidino-N-{2-oxo-2-[4-(5-m-tolyl-2H-pyrazol-3-yl)-piperidin-1-yl]-ethyl}-acetamide | CHEMBL106672 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H37N7O2 | ||
Mol. Mass. | 479.6177 | ||
SMILES | Cc1cccc(c1)-c1cc([nH]n1)C1CCN(CC1)C(=O)CNC(=O)[C@H](N=C(N)N)C1CCCCC1 |wD:24.27,(-6.99,-8.1,;-6.99,-6.56,;-8.32,-5.79,;-8.32,-4.25,;-6.99,-3.48,;-5.64,-4.25,;-5.64,-5.79,;-4.36,-3.39,;-2.91,-3.93,;-1.96,-2.71,;-2.82,-1.45,;-4.31,-1.87,;-.42,-2.78,;.29,-4.15,;1.82,-4.21,;2.64,-2.91,;1.92,-1.55,;.38,-1.48,;4.18,-2.97,;4.9,-4.34,;5,-1.68,;6.54,-1.73,;7.37,-.43,;6.65,.92,;8.91,-.5,;9.73,.81,;11.27,.74,;11.97,-.63,;12.09,2.04,;9.61,-1.87,;8.78,-3.16,;9.49,-4.52,;11.03,-4.59,;11.85,-3.3,;11.15,-1.92,)| | ||
Structure |