| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Interleukin-2 receptor subunit alpha |
|---|
| Ligand | BDBM50147995 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_89085 (CHEMBL698595) |
|---|
| IC50 | 80000±n/a nM |
|---|
| Citation |  Raimundo, BC; Oslob, JD; Braisted, AC; Hyde, J; McDowell, RS; Randal, M; Waal, ND; Wilkinson, J; Yu, CH; Arkin, MR Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions. J Med Chem47:3111-30 (2004) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Interleukin-2 receptor subunit alpha |
|---|
| Name: | Interleukin-2 receptor subunit alpha |
|---|
| Synonyms: | CD_antigen=CD25 | IL-2 receptor alpha subunit | IL-2-RA | IL2-RA | IL2RA_MOUSE | Il2r | Il2ra | Interleukin-2 receptor alpha chain | p55 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 30733.96 |
|---|
| Organism: | Mus musculus |
|---|
| Description: | ChEMBL_89085 |
|---|
| Residue: | 268 |
|---|
| Sequence: | MEPRLLMLGFLSLTIVPSCRAELCLYDPPEVPNATFKALSYKNGTILNCECKRGFRRLKE
LVYMRCLGNSWSSNCQCTSNSHDKSRKQVTAQLEHQKEQQTTTDMQKPTQSMHQENLTGH
CREPPPWKHEDSKRIYHFVEGQSVHYECIPGYKALQRGPAISICKMKCGKTGWTQPQLTC
VDEREHHRFLASEESQGSRNSSPESETSCPITTTDFPQPTETTAMTETFVLTMEYKVAVA
SCLFLLISILLLSGLTWQHRWRKSRRTI
|
|
|
|---|
| BDBM50147995 |
|---|
| n/a |
|---|
| Name | BDBM50147995 |
|---|
| Synonyms: | (S)-2-[2-((S)-2-Guanidino-3-methyl-butyrylamino)-acetylamino]-3-(4-phenylethynyl-phenyl)-propionic acid methyl ester | CHEMBL318396 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H31N5O4 |
|---|
| Mol. Mass. | 477.5554 |
|---|
| SMILES | [#6]-[#8]-[#6](=O)-[#6@H](-[#6]-c1ccc(cc1)C#Cc1ccccc1)-[#7]-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](\[#7]=[#6](/[#7])-[#7])-[#6](-[#6])-[#6] |
|---|
| Structure | 
|
|---|
Search and Browse
