Ki Summary

Reaction Details

Report a problem with these data

Target

Interleukin-2 receptor subunit alpha

Ligand

BDBM50147998

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_89084 (CHEMBL878448)

IC50

50000±n/a nM

Citation

Raimundo, BC; Oslob, JD; Braisted, AC; Hyde, J; McDowell, RS; Randal, M; Waal, ND; Wilkinson, J; Yu, CH; Arkin, MR Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions. J Med Chem47:3111-30 (2004) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Interleukin-2 receptor subunit alpha

Name:

Interleukin-2 receptor subunit alpha

Synonyms:

Type:

PROTEIN

Mol. Mass.:

30733.96

Organism:

Mus musculus

Description:

ChEMBL_89085

Residue:

268

Sequence:

MEPRLLMLGFLSLTIVPSCRAELCLYDPPEVPNATFKALSYKNGTILNCECKRGFRRLKE
LVYMRCLGNSWSSNCQCTSNSHDKSRKQVTAQLEHQKEQQTTTDMQKPTQSMHQENLTGH
CREPPPWKHEDSKRIYHFVEGQSVHYECIPGYKALQRGPAISICKMKCGKTGWTQPQLTC
VDEREHHRFLASEESQGSRNSSPESETSCPITTTDFPQPTETTAMTETFVLTMEYKVAVA
SCLFLLISILLLSGLTWQHRWRKSRRTI

BDBM50147998

n/a

Name

BDBM50147998

Synonyms:

2-(R)-Cyclohexyl-2-guanidino-N-{2-oxo-2-[4-(5-o-tolyl-2H-pyrazol-3-yl)-piperidin-1-yl]-ethyl}-acetamide | CHEMBL104791

Type

Small organic molecule

Emp. Form.

C26H37N7O2

Mol. Mass.

479.6177

SMILES

Cc1ccccc1-c1cc([nH]n1)C1CCN(CC1)C(=O)CNC(=O)[C@H](N=C(N)N)C1CCCCC1 |wD:24.27,(-4.31,-6.56,;-5.64,-5.79,;-6.99,-6.56,;-8.32,-5.79,;-8.32,-4.25,;-6.99,-3.48,;-5.64,-4.25,;-4.36,-3.39,;-2.91,-3.93,;-1.96,-2.71,;-2.82,-1.45,;-4.31,-1.87,;-.42,-2.78,;.29,-4.15,;1.82,-4.21,;2.64,-2.91,;1.92,-1.55,;.38,-1.48,;4.18,-2.97,;4.9,-4.34,;5,-1.68,;6.54,-1.73,;7.37,-.43,;6.65,.92,;8.91,-.5,;9.73,.81,;11.27,.74,;11.97,-.63,;12.09,2.04,;9.61,-1.87,;8.78,-3.16,;9.49,-4.52,;11.03,-4.59,;11.85,-3.3,;11.15,-1.92,)|

Structure