| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-2 receptor subunit alpha |
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| Ligand | BDBM50148001 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_89084 (CHEMBL878448) |
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| IC50 | 3500±n/a nM |
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| Citation |  Raimundo, BC; Oslob, JD; Braisted, AC; Hyde, J; McDowell, RS; Randal, M; Waal, ND; Wilkinson, J; Yu, CH; Arkin, MR Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions. J Med Chem47:3111-30 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-2 receptor subunit alpha |
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| Name: | Interleukin-2 receptor subunit alpha |
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| Synonyms: | CD_antigen=CD25 | IL-2 receptor alpha subunit | IL-2-RA | IL2-RA | IL2RA_MOUSE | Il2r | Il2ra | Interleukin-2 receptor alpha chain | p55 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30733.96 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_89085 |
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| Residue: | 268 |
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| Sequence: | MEPRLLMLGFLSLTIVPSCRAELCLYDPPEVPNATFKALSYKNGTILNCECKRGFRRLKE
LVYMRCLGNSWSSNCQCTSNSHDKSRKQVTAQLEHQKEQQTTTDMQKPTQSMHQENLTGH
CREPPPWKHEDSKRIYHFVEGQSVHYECIPGYKALQRGPAISICKMKCGKTGWTQPQLTC
VDEREHHRFLASEESQGSRNSSPESETSCPITTTDFPQPTETTAMTETFVLTMEYKVAVA
SCLFLLISILLLSGLTWQHRWRKSRRTI
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| BDBM50148001 |
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| n/a |
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| Name | BDBM50148001 |
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| Synonyms: | 2-Guanidino-4-methyl-pentanoic acid (2-{4-[5-(2,3-dichloro-4-methoxy-phenyl)-2-methyl-2H-pyrazol-3-yl]-piperidin-1-yl}-2-oxo-ethyl)-amide | CHEMBL421412 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H35Cl2N7O3 |
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| Mol. Mass. | 552.497 |
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| SMILES | [#6]-[#8]-c1ccc(-c2cc(-[#6]-3-[#6]-[#6]-[#7](-[#6]-[#6]-3)-[#6](=O)-[#6]-[#7]-[#6](=O)-[#6@@H](-[#6]-[#6](-[#6])-[#6])\[#7]=[#6](/[#7])-[#7])n(-[#6])n2)c(Cl)c1Cl |
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| Structure | 
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