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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Neuropeptide Y receptor type 5 | ||
| Ligand | BDBM50170192 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_306270 (CHEMBL874561) | ||
| IC50 | 2400±n/a nM | ||
| Citation |  Kanuma, K; Omodera, K; Nishiguchi, M; Funakoshi, T; Chaki, S; Semple, G; Tran, TA; Kramer, B; Hsu, D; Casper, M; Thomsen, B; Sekiguchi, Y Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1. Bioorg Med Chem Lett15:3853-6 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Neuropeptide Y receptor type 5 | |||
| Name: | Neuropeptide Y receptor type 5 | ||
| Synonyms: | NPY-Y5 | NPY-Y5 receptor | NPY5-R | NPY5R | NPY5R_HUMAN | NPYR5 | NPYY5 | Neuropeptide Y receptor type 5 | Neuropeptide Y receptor type 5 ( NPY Y5) | Y5 receptor | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 50746.64 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q15761 | ||
| Residue: | 445 | ||
| Sequence: |
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| BDBM50170192 | |||
| n/a | |||
| Name | BDBM50170192 | ||
| Synonyms: | CHEMBL181466 | cis-N*2*-{4-[(4-Bromo-2-trifluoromethoxy-benzylamino)-methyl]-cyclohexyl}-N*4*,N*4*-dimethyl-quinazoline-2,4-diamine | ||
| Type | Small organic molecule | ||
| Emp. Form. | C25H29BrF3N5O | ||
| Mol. Mass. | 552.43 | ||
| SMILES | CN(C)c1nc(NC2CCC(CNCc3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12 |(9.05,-31.64,;7.7,-32.41,;6.37,-31.64,;7.7,-33.96,;9.05,-34.73,;9.05,-36.27,;10.39,-37.07,;11.49,-35.97,;11.48,-37.5,;12.8,-38.28,;14.15,-37.51,;15.48,-38.28,;16.81,-37.51,;18.14,-38.28,;19.48,-37.49,;19.46,-35.97,;20.79,-35.17,;22.13,-35.95,;23.46,-35.17,;22.14,-37.49,;20.82,-38.26,;20.82,-39.8,;22.15,-40.58,;23.67,-39.99,;23.38,-41.28,;22.42,-42.17,;14.15,-35.97,;12.81,-35.2,;7.7,-37.04,;6.37,-36.27,;5.03,-37.04,;3.7,-36.27,;3.7,-34.75,;5.03,-33.96,;6.37,-34.73,)| | ||
| Structure | 
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