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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Melanin-concentrating hormone receptor 1 | ||
| Ligand | BDBM50170187 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_306788 (CHEMBL832373) | ||
| IC50 | 5800±n/a nM | ||
| Citation |  Kanuma, K; Omodera, K; Nishiguchi, M; Funakoshi, T; Chaki, S; Semple, G; Tran, TA; Kramer, B; Hsu, D; Casper, M; Thomsen, B; Sekiguchi, Y Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1. Bioorg Med Chem Lett15:3853-6 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Melanin-concentrating hormone receptor 1 | |||
| Name: | Melanin-concentrating hormone receptor 1 | ||
| Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 45976.27 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays. | ||
| Residue: | 422 | ||
| Sequence: |
| ||
| BDBM50170187 | |||
| n/a | |||
| Name | BDBM50170187 | ||
| Synonyms: | CHEMBL181727 | trans-4-Bromo-N-{4-[(4-dimethylamino-quinazolin-2-ylamino)-methyl]-cyclohexylmethyl}-N-methyl-2-trifluoromethoxy-benzenesulfonamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C26H31BrF3N5O3S | ||
| Mol. Mass. | 630.52 | ||
| SMILES | CN(C)c1nc(NCC2CCC(CN(C)S(=O)(=O)c3ccc(Br)cc3OC(F)(F)F)CC2)nc2ccccc12 |(-6.25,5.67,;-7.59,4.9,;-8.94,5.67,;-7.59,3.36,;-6.25,2.59,;-6.25,1.04,;-4.9,.25,;-3.57,1.03,;-2.24,.26,;-2.24,-1.27,;-.93,-2.04,;.42,-1.29,;1.75,-2.06,;3.08,-1.29,;3.07,.26,;4.42,-2.06,;4.4,-3.6,;4.4,-.51,;5.75,-1.27,;5.73,.26,;7.06,1.04,;8.4,.28,;9.73,1.07,;8.41,-1.26,;7.09,-2.04,;7.09,-3.58,;8.42,-4.35,;9.65,-5.05,;8.69,-5.93,;9.94,-3.77,;.42,.25,;-.91,1.03,;-7.59,.27,;-8.92,1.04,;-10.25,.27,;-11.59,1.04,;-11.59,2.57,;-10.25,3.36,;-8.92,2.59,)| | ||
| Structure | 
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