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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Melanin-concentrating hormone receptor 1 | ||
| Ligand | BDBM50170198 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_306788 (CHEMBL832373) | ||
| IC50 | 9.5±n/a nM | ||
| Citation |  Kanuma, K; Omodera, K; Nishiguchi, M; Funakoshi, T; Chaki, S; Semple, G; Tran, TA; Kramer, B; Hsu, D; Casper, M; Thomsen, B; Sekiguchi, Y Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1. Bioorg Med Chem Lett15:3853-6 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Melanin-concentrating hormone receptor 1 | |||
| Name: | Melanin-concentrating hormone receptor 1 | ||
| Synonyms: | G-protein coupled receptor 24 | GPR24 | MCH receptor 1 | MCH-1R | MCH-R1 | MCHR | MCHR-1 | MCHR1 | MCHR1_HUMAN | Melanin Concentrating Hormone 1 | Melanin-Concentrating Hormone Receptor 1 (MCH1R) | Melanin-concentrating hormone receptor | Melanin-concentrating hormone receptor 1 (MCH-1) | Melanin-concentrating hormone receptor 1 (MCH1) | Melanin-concentrating hormone receptor 1 (MCHR-1) | Melanin-concentrating hormone receptor 1 (MCHR1) | SLC-1 | SLC1 | Somatostatin receptor-like protein | ||
| Type: | G Protein-Coupled Receptor (GPCR) | ||
| Mol. Mass.: | 45976.27 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Membranes from CHO-K1 cells stably expressing human MCH1R were used in assays. | ||
| Residue: | 422 | ||
| Sequence: |
| ||
| BDBM50170198 | |||
| n/a | |||
| Name | BDBM50170198 | ||
| Synonyms: | CHEMBL362193 | N-[4-(4-Dimethylamino-quinazolin-2-ylamino)-cyclohexyl]-3-fluoro-benzamide | ||
| Type | Small organic molecule | ||
| Emp. Form. | C23H26FN5O | ||
| Mol. Mass. | 407.4838 | ||
| SMILES | CN(C)c1nc(N[C@@H]2CC[C@@H](CC2)NC(=O)c2cccc(F)c2)nc2ccccc12 |wU:10.13,7.6,(1.73,2.57,;.4,1.79,;-.93,2.56,;.4,.25,;1.75,-.51,;1.76,-2.06,;3.09,-2.81,;4.42,-2.05,;5.76,-2.83,;7.09,-2.06,;7.09,-.52,;5.75,.25,;4.42,-.52,;8.43,.25,;9.76,-.52,;9.76,-2.06,;11.09,.25,;12.42,-.52,;13.75,.25,;13.75,1.79,;12.41,2.56,;12.41,4.1,;11.09,1.79,;.43,-2.83,;-.91,-2.06,;-2.26,-2.85,;-3.59,-2.08,;-3.59,-.54,;-2.26,.25,;-.91,-.52,)| | ||
| Structure | 
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