| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 2 |
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| Ligand | BDBM50157949 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_303334 (CHEMBL840150) |
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| Ki | 1.6±n/a nM |
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| Citation |  Turkmen, H; Durgun, M; Yilmaztekin, S; Emul, M; Innocenti, A; Vullo, D; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Novel sulfanilamide/acetazolamide derivatives obtained by the tail approach and their interaction with the cytosolic isozymes I and II, and the tumor-associated isozyme IX. Bioorg Med Chem Lett15:367-72 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 2 |
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| Name: | Carbonic anhydrase 2 |
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| Synonyms: | CA-II | CA2 | CAC | CAH2_HUMAN | Carbonate dehydratase II | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase 2 (CA-II) | Carbonic anhydrase 2 (Recombinant CA II) | Carbonic anhydrase C | Carbonic anhydrase II (CA II) | Carbonic anhydrase II (CA-II) | Carbonic anhydrase II (CAII) | Carbonic anhydrase II (hCA II) | Carbonic anhydrase isoenzyme II (hCA II) |
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| Type: | Enzyme |
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| Mol. Mass.: | 29250.71 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00918 |
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| Residue: | 260 |
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| Sequence: | MSHHWGYGKHNGPEHWHKDFPIAKGERQSPVDIDTHTAKYDPSLKPLSVSYDQATSLRIL
NNGHAFNVEFDDSQDKAVLKGGPLDGTYRLIQFHFHWGSLDGQGSEHTVDKKKYAAELHL
VHWNTKYGDFGKAVQQPDGLAVLGIFLKVGSAKPGLQKVVDVLDSIKTKGKSADFTNFDP
RGLLPESLDYWTYPGSLTTPPLLECVTWIVLKEPISVSSEQVLKFRKLNFNGEGEPEELM
VDNWRPAQPLKNRQIKASFK
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| BDBM50157949 |
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| n/a |
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| Name | BDBM50157949 |
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| Synonyms: | 2-(4-Methyl-piperazin-1-yl)-N-(5-sulfamoyl-[1,3,4]thiadiazol-2-yl)-acetamide | 2-(4-methylpiperazin-1-yl)-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)acetamide | CHEMBL179897 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H16N6O3S2 |
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| Mol. Mass. | 320.392 |
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| SMILES | CN1CCN(CC(=O)Nc2nnc(s2)S(N)(=O)=O)CC1 |
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| Structure | 
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