Reaction Details |
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Target | Carbonic anhydrase 4 |
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Ligand | BDBM10887 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_302691 (CHEMBL838574) |
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Ki | 54±n/a nM |
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Citation | Innocenti, A; Firnges, MA; Antel, J; Wurl, M; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides. Bioorg Med Chem Lett15:1149-54 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Carbonic anhydrase 4 |
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Name: | Carbonic anhydrase 4 |
Synonyms: | CA-IV | CA4 | CAH4_BOVIN | Carbonate dehydratase IV | Carbonic Anhydrase IV | Carbonic anhydrase | Carbonic anhydrase 4 |
Type: | Enzyme |
Mol. Mass.: | 35152.74 |
Organism: | Bos taurus (bovine) |
Description: | Bovine isozyme, isolated from lung microsomes |
Residue: | 312 |
Sequence: | MRLLLALLVLAAAPPQARAASHWCYQIQVKPSNYTCLEPDEWEGSCQNNRQSPVNIVTAK
TQLDPNLGRFSFSGYNMKHQWVVQNNGHTVMVLLENKPSIAGGGLSTRYQATQLHLHWSR
AMDRGSEHSFDGERFAMEMHIVHEKEKGLSGNASQNQFAEDEIAVLAFMVEDGSKNVNFQ
PLVEALSDIPRPNMNTTMKEGVSLFDLLPEEESLRHYFRYLGSLTTPTCDEKVVWTVFQK
PIQLHRDQILAFSQKLFYDDQQKVNMTDNVRPVQSLGQRQVFRSGAPGLLLAQPLPTLLA
PVLACLTVGFLR
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BDBM10887 |
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n/a |
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Name | BDBM10887 |
Synonyms: | Sulfamate 7 | Topiramate (TPM) | US11535599, Example topiramate | [(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl sulfamate |
Type | Small organic molecule |
Emp. Form. | C12H21NO8S |
Mol. Mass. | 339.362 |
SMILES | CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 |r| |
Structure |
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