| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase 1 |
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| Ligand | BDBM10873 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_302370 (CHEMBL830339) |
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| Ki | 109±n/a nM |
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| Citation |  Vullo, D; Innocenti, A; Nishimori, I; Pastorek, J; Scozzafava, A; Pastoreková, S; Supuran, CT Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs? Bioorg Med Chem Lett15:963-9 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase 1 |
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| Name: | Carbonic anhydrase 1 |
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| Synonyms: | CA-I | CA1 | CAB | CAH1_HUMAN | Carbonate dehydratase I | Carbonic anhydrase | Carbonic anhydrase 1 (CA I) | Carbonic anhydrase 1 (CA-I) | Carbonic anhydrase 1 (Recombinant CA I) | Carbonic anhydrase 2 (CA II) | Carbonic anhydrase B | Carbonic anhydrase I | Carbonic anhydrase I (CA I) | Carbonic anhydrase I (CA-I) | Carbonic anhydrase I (CAI) | Carbonic anhydrase I (hCA I) | Carbonic anhydrase isoenzyme I (hCA I) | hCA |
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| Type: | Enzyme |
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| Mol. Mass.: | 28873.37 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00915 |
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| Residue: | 261 |
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| Sequence: | MASPDWGYDDKNGPEQWSKLYPIANGNNQSPVDIKTSETKHDTSLKPISVSYNPATAKEI
INVGHSFHVNFEDNDNRSVLKGGPFSDSYRLFQFHFHWGSTNEHGSEHTVDGVKYSAELH
VAHWNSAKYSSLAEAASKADGLAVIGVLMKVGEANPKLQKVLDALQAIKTKGKRAPFTNF
DPSTLLPSSLDFWTYPGSLTHPPLYESVTWIICKESISVSSEQLAQFRSLLSNVEGDNAV
PMQHNNRPTQPLKGRTVRASF
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| BDBM10873 |
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| n/a |
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| Name | BDBM10873 |
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| Synonyms: | 4-[(2-aminopyrimidin-4-yl)amino]benzene-1-sulfonamide | CHEMBL6633 | US9616064, Compound 1aa | aromatic/heteroaromatic sulfonamide 18 |
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| Type | Small organic molecule |
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| Emp. Form. | C10H11N5O2S |
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| Mol. Mass. | 265.292 |
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| SMILES | Nc1nccc(Nc2ccc(cc2)S(N)(=O)=O)n1 |
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| Structure | 
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