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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Neuronal acetylcholine receptor subunit alpha-4/beta-2 | ||
| Ligand | BDBM50164928 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_303090 (CHEMBL828762) | ||
| Ki | >10000±n/a nM | ||
| Citation |  Mazurov, A; Klucik, J; Miao, L; Phillips, TY; Seamans, A; Schmitt, JD; Hauser, TA; Johnson, RT; Miller, C 2-(Arylmethyl)-3-substituted quinuclidines as selective alpha 7 nicotinic receptor ligands. Bioorg Med Chem Lett15:2073-7 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Neuronal acetylcholine receptor subunit alpha-4/beta-2 | |||
| Name: | Neuronal acetylcholine receptor subunit alpha-4/beta-2 | ||
| Synonyms: | Neuronal acetylcholine receptor Alpha-4/Beta-2 | Neuronal acetylcholine receptor protein alpha-4/beta-2 subunit | Neuronal acetylcholine receptor; alpha4/beta2 | nAChR subtypes alpha4 beta2 | ||
| Type: | Protein | ||
| Mol. Mass.: | n/a | ||
| Description: | n/a | ||
| Components: | This complex has 2 components. | ||
| Component 1 | |||
| Name: | Neuronal acetylcholine receptor subunit alpha-4 | ||
| Synonyms: | ACHA4_HUMAN | CHRNA4 | CHRNA4 protein | NACRA4 | Neuronal acetylcholine receptor protein alpha-4 subunit | Neuronal acetylcholine receptor subunit alpha 4 beta 2 | Nicotinic acetylcholine receptor alpha4/beta2/alpha5 | ||
| Type: | n/a | ||
| Mol. Mass.: | 69963.49 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | NACHRA4 | ||
| Residue: | 627 | ||
| Sequence: |
| ||
| Component 2 | |||
| Name: | Neuronal acetylcholine receptor subunit beta-2 | ||
| Synonyms: | ACHB2_HUMAN | CHRNB2 | Neuronal acetylcholine receptor protein beta-2 subunit | Nicotinic acetylcholine receptor alpha3/beta2/alpha5 | ||
| Type: | Protein | ||
| Mol. Mass.: | 57020.50 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P17787 | ||
| Residue: | 502 | ||
| Sequence: |
| ||
| BDBM50164928 | |||
| n/a | |||
| Name | BDBM50164928 | ||
| Synonyms: | (4-Fluoro-phenyl)-carbamic acid (2R,3R)-2-pyridin-3-ylmethyl-1-aza-bicyclo[2.2.2]oct-3-yl ester | CHEMBL193441 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H22FN3O2 | ||
| Mol. Mass. | 355.406 | ||
| SMILES | Fc1ccc(NC(=O)O[C@@H]2C3CCN(CC3)[C@@H]2Cc2cccnc2)cc1 |wU:9.8,16.18,(17.5,.23,;16.15,1,;16.15,2.56,;14.82,3.33,;13.49,2.56,;12.16,3.33,;10.83,2.56,;10.83,1.02,;9.5,3.34,;8.17,2.57,;6.84,3.35,;6.05,2.02,;7.38,1.25,;6.84,.27,;5.51,1.03,;5.51,2.57,;8.17,1.03,;9.5,.26,;9.5,-1.28,;8.15,-2.04,;8.15,-3.58,;9.5,-4.35,;10.83,-3.58,;10.83,-2.04,;13.49,1.02,;14.82,.25,)| | ||
| Structure | 
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