Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM50159007 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_303199 (CHEMBL829825) |
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Ki | 700±n/a nM |
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Citation | Costantino, L; Gandolfi, F; Sorbi, C; Franchini, S; Prezzavento, O; Vittorio, F; Ronsisvalle, G; Leonardi, A; Poggesi, E; Brasili, L Synthesis and structure-activity relationships of 1-aralkyl-4-benzylpiperidine and 1-aralkyl-4-benzylpiperazine derivatives as potent sigma ligands. J Med Chem48:266-73 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 25124.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99720 |
Residue: | 223 |
Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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BDBM50159007 |
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n/a |
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Name | BDBM50159007 |
Synonyms: | 3-(4-Benzyl-piperidin-1-ylmethyl)-chromen-4-one | CHEMBL426958 |
Type | Small organic molecule |
Emp. Form. | C22H23NO2 |
Mol. Mass. | 333.4235 |
SMILES | O=c1c(CN2CCC(Cc3ccccc3)CC2)coc2ccccc12 |
Structure |
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