Ki Summary

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Target

Mitogen-activated protein kinase 10

Ligand

BDBM50170006

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_304976 (CHEMBL829309)

IC50

600±n/a nM

Citation

Gaillard, P; Jeanclaude-Etter, I; Ardissone, V; Arkinstall, S; Cambet, Y; Camps, M; Chabert, C; Church, D; Cirillo, R; Gretener, D; Halazy, S; Nichols, A; Szyndralewiez, C; Vitte, PA; Gotteland, JP Design and synthesis of the first generation of novel potent, selective, and in vivo active (benzothiazol-2-yl)acetonitrile inhibitors of the c-Jun N-terminal kinase. J Med Chem48:4596-607 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Mitogen-activated protein kinase 10

Name:

Mitogen-activated protein kinase 10

Synonyms:

Jnk3 | MK10_RAT | Mapk10 | Prkm10 | c-Jun N-terminal kinase 3

Type:

PROTEIN

Mol. Mass.:

52534.34

Organism:

Rattus norvegicus

Description:

ChEMBL_1460661

Residue:

464

Sequence:

MSLHFLYYCSEPTLDVKIAFCQGFDKHVDVSSVVKHYNMSKSKVDNQFYSVEVGDSTFTV
LKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNH
KNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHL
HSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGY
KENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVEN
RPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYIN
VWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAA
VNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR

BDBM50170006

n/a

Name

BDBM50170006

Synonyms:

CHEMBL190250 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[2-(4-nitro-phenyl)-ethylamino]-pyrimidin-4-yl}-acetonitrile

Type

Small organic molecule

Emp. Form.

C21H16N6O2S

Mol. Mass.

416.456

SMILES

[O-][N+](=O)c1ccc(CCNc2nccc(n2)C(=C=[N-])c2[nH+]c3ccccc3s2)cc1

Structure