| Reaction Details |
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 | Report a problem with these data |
| Target | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase |
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| Ligand | BDBM79181 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_303691 (CHEMBL829736) |
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| Ki | 8±n/a nM |
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| Citation |  Laggner, C; Schieferer, C; Fiechtner, B; Poles, G; Hoffmann, RD; Glossmann, H; Langer, T; Moebius, FF Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening. J Med Chem48:4754-64 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase |
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| Name: | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase |
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| Synonyms: | 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase/Delta(24)-sterol reductase | 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase | Anti-estrogen binding site (AEBS) | Cholestenol Delta-isomerase | D8-D7 sterol isomerase | Delta(8)-Delta(7) sterol isomerase | EBP | EBP_HUMAN | Emopamil-binding protein |
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| Type: | PROTEIN |
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| Mol. Mass.: | 26358.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_873432 |
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| Residue: | 230 |
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| Sequence: | MTTNAGPLHPYWPQHLRLDNFVPNDRPTWHILAGLFSVTGVLVVTTWLLSGRAAVVPLGT
WRRLSLCWFAVCGFIHLVIEGWFVLYYEDLLGDQAFLSQLWKEYAKGDSRYILGDNFTVC
METITACLWGPLSLWVVIAFLRQHPLRFILQLVVSVGQIYGDVLYFLTEHRDGFQHGELG
HPLYFWFYFVFMNALWLVLPGVLVLDAVKHLTHAQSTLDAKATKAKSKKN
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| BDBM79181 |
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| n/a |
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| Name | BDBM79181 |
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| Synonyms: | 10-[3-(4-methyl-1-piperazinyl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride | 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride | 10-[3-(4-methylpiperazino)propyl]-2-(trifluoromethyl)phenothiazine;hydrochloride | MLS001146870 | SMR000059133 | TRIFLUOPERAZINE | TRIFLUOPERAZINE DIHYDROCHLORIDE | Trifluperazine | US11542290, Compound Trifluoperazine | cid_2913535 | cid_5566 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H24F3N3S |
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| Mol. Mass. | 407.496 |
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| SMILES | CN1CCN(CCCN2c3ccccc3Sc3ccc(cc23)C(F)(F)F)CC1 |
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| Structure | 
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