| Reaction Details |
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 | Report a problem with these data |
| Target | C-8 sterol isomerase ERG2 |
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| Ligand | BDBM50170663 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_303390 (CHEMBL839961) |
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| Ki | 1000±n/a nM |
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| Citation |  Laggner, C; Schieferer, C; Fiechtner, B; Poles, G; Hoffmann, RD; Glossmann, H; Langer, T; Moebius, FF Discovery of high-affinity ligands of sigma1 receptor, ERG2, and emopamil binding protein by pharmacophore modeling and virtual screening. J Med Chem48:4754-64 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-8 sterol isomerase ERG2 |
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| Name: | C-8 sterol isomerase ERG2 |
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| Synonyms: | C-8 sterol isomerase | Delta-8--delta-7 sterol isomerase | ERG2 | ERG2_YEAST |
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| Type: | PROTEIN |
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| Mol. Mass.: | 24892.29 |
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| Organism: | Saccharomyces cerevisiae |
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| Description: | ChEMBL_303390 |
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| Residue: | 222 |
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| Sequence: | MKFFPLLLLIGVVGYIMNVLFTTWLPTNYMFDPKTLNEICNSVISKHNAAEGLSTEDLLQ
DVRDALASHYGDEYINRYVKEEWVFNNAGGAMGQMIILHASVSEYLILFGTAVGTEGHTG
VHFADDYFTILHGTQIAALPYATEAEVYTPGMTHHLKKGYAKQYSMPGGSFALELAQGWI
PCMLPFGFLDTFSSTLDLYTLYRTVYLTARDMGKNLLQNKKF
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| BDBM50170663 |
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| n/a |
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| Name | BDBM50170663 |
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| Synonyms: | (7S,8R)-7,8-Dimethyl-6-(3-methyl-but-2-enylamino)-8-propyl-5,6,7,8-tetrahydro-naphthalen-2-ol | CHEMBL305593 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H27NO |
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| Mol. Mass. | 285.4238 |
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| SMILES | [H][C@@]1([#6])[#6]-2-[#6]-c3ccc(-[#8])cc3[C@]1([#6])[#6]-[#6]-[#7]-2-[#6]\[#6]=[#6](\[#6])-[#6] |TLB:2:1:11.5.4:16.14.15,17:16:1:11.5.4,10:11:1:16.14.15| |
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| Structure | 
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