Ki Summary

Reaction Details

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Target

Prolyl endopeptidase

Ligand

BDBM50051547

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_306908 (CHEMBL828351)

7±n/a

IC50

29±n/a nM

Comments

extracted

Citation

Jarho, EM; Wallén, EA; Christiaans, JA; Forsberg, MM; Venäläinen, JI; Männistö, PT; Gynther, J; Poso, A Dicarboxylic acid azacycle l-prolyl-pyrrolidine amides as prolyl oligopeptidase inhibitors and three-dimensional quantitative structure-activity relationship of the enzyme-inhibitor interactions. J Med Chem48:4772-82 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Prolyl endopeptidase

Name:

Prolyl endopeptidase

Synonyms:

3.4.21.26 | PE | PPCE_PIG | PREP | Post-proline cleaving enzyme

Type:

n/a

Mol. Mass.:

80758.04

Organism:

Sus scrofa

Description:

n/a

Residue:

710

Sequence:

MLSFQYPDVYRDETAIQDYHGHKVCDPYAWLEDPDSEQTKAFVEAQNKITVPFLEQCPIR
GLYKERMTELYDYPKYSCHFKKGKRYFYFYNTGLQNQRVLYVQDSLEGEARVFLDPNILS
DDGTVALRGYAFSEDGEYFAYGLSASGSDWVTIKFMKVDGAKELPDVLERVKFSCMAWTH
DGKGMFYNAYPQQDGKSDGTETSTNLHQKLYYHVLGTDQSEDILCAEFPDEPKWMGGAEL
SDDGRYVLLSIREGCDPVNRLWYCDLQQESNGITGILKWVKLIDNFEGEYDYVTNEGTVF
TFKTNRHSPNYRLINIDFTDPEESKWKVLVPEHEKDVLEWVACVRSNFLVLCYLHDVKNT
LQLHDLATGALLKIFPLEVGSVVGYSGQKKDTEIFYQFTSFLSPGIIYHCDLTKEELEPR
VFREVTVKGIDASDYQTVQIFYPSKDGTKIPMFIVHKKGIKLDGSHPAFLYGYGGFNISI
TPNYSVSRLIFVRHMGGVLAVANIRGGGEYGETWHKGGILANKQNCFDDFQCAAEYLIKE
GYTSPKRLTINGGSNGGLLVATCANQRPDLFGCVIAQVGVMDMLKFHKYTIGHAWTTDYG
CSDSKQHFEWLIKYSPLHNVKLPEADDIQYPSMLLLTADHDDRVVPLHSLKFIATLQYIV
GRSRKQNNPLLIHVDTKAGHGAGKPTAKVIEEVSDMFAFIARCLNIDWIP

BDBM50051547

n/a

Name

BDBM50051547

Synonyms:

(S)-2-(Pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester | (S)-tert-butyl 2-(pyrrolidine-1-carbonyl)pyrrolidine-1-carboxylate | CHEMBL311364

Type

Small organic molecule

Emp. Form.

C14H24N2O3

Mol. Mass.

268.352

SMILES

CC(C)(C)OC(=O)N1CCC[C@H]1C(=O)N1CCCC1

Structure