| Reaction Details |
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 | Report a problem with these data |
| Target | Metabotropic glutamate receptor 3 |
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| Ligand | BDBM50171487 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_303473 (CHEMBL838848) |
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| Ki | >10000±n/a nM |
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| Citation |  Bueno, AB; Collado, I; de Dios, A; Domínguez, C; Martín, JA; Martín, LM; Martínez-Grau, MA; Montero, C; Pedregal, C; Catlow, J; Coffey, DS; Clay, MP; Dantzig, AH; Lindstrom, T; Monn, JA; Jiang, H; Schoepp, DD; Stratford, RE; Tabas, LB; Tizzano, JP; Wright, RA; Herin, MF Dipeptides as effective prodrugs of the unnatural amino acid (+)-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (LY354740), a selective group II metabotropic glutamate receptor agonist. J Med Chem48:5305-20 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Metabotropic glutamate receptor 3 |
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| Name: | Metabotropic glutamate receptor 3 |
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| Synonyms: | GPRC1C | GRM3 | GRM3_HUMAN | MGLUR3 | metabotropic glutamate 3 | metabotropic glutamate 3/1a | metabotropic glutamate 3/1c |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 98889.09 |
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| Organism: | Homo sapiens (Human) |
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| Description: | metabotropic glutamate 1c 0 HUMAN::Q14832 |
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| Residue: | 879 |
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| Sequence: | MKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRI
NEDRGIQRLEAMLFAIDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKV
DEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSD
KSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNIC
IATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVAS
DGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQ
CSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCD
AMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSY
LKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYL
ADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIK
HNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALL
TKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLA
EKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCI
IWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIILFQPQKNVVTHRLH
LNRFSVSGTGTTYSQSSASTYVPTVCNGREVLDSTTSSL
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| BDBM50171487 |
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| n/a |
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| Name | BDBM50171487 |
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| Synonyms: | (1S,2S,5R,6S)-2-((S)-2-Amino-propionylamino)-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid; hydrochloride | CHEMBL538325 |
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| Type | Small organic molecule |
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| Emp. Form. | C11H16N2O5 |
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| Mol. Mass. | 256.2551 |
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| SMILES | C[C@H](N)C(=O)N[C@]1(CC[C@H]2[C@@H]([C@@H]12)C(O)=O)C(O)=O |
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| Structure | 
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