| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 2b |
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| Ligand | BDBM50134800 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305568 (CHEMBL827162) |
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| IC50 | 270±n/a nM |
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| Citation |  Mai, A; Massa, S; Pezzi, R; Simeoni, S; Rotili, D; Nebbioso, A; Scognamiglio, A; Altucci, L; Loidl, P; Brosch, G Class II (IIa)-selective histone deacetylase inhibitors. 1. Synthesis and biological evaluation of novel (aryloxopropenyl)pyrrolyl hydroxyamides. J Med Chem48:3344-53 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 2b |
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| Name: | Histone deacetylase 2b |
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| Synonyms: | Histone deacetylase HD2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 30785.07 |
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| Organism: | Zea mays |
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| Description: | ChEMBL_87549 |
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| Residue: | 286 |
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| Sequence: | MEVGGQEVKPGATVSCKVGDGLVIHLSQAALGESKKASENAILSVNIDDKKLVLGTLSVE
KHPQISCDLVFDKDFELPHNSKTRSVFFRGYKSPVPLFESNSGEDSSDEELKTDQIPLQN
NEIKISAAKVPAKDDDDDVFIILAMMMMIYSSDDDDDDFTTSDSDNEMSEEDDSSDEDEM
SEEDDSSDEDEMSGGADPSDDSSDESGSEHTSAPKKTDVVVGKKRAIKAEAPYGKKAKSE
QSSQKTGDKASTSHPAKQSIKTPADKSRKTPTADKKSPKSGSHGCK
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| BDBM50134800 |
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| n/a |
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| Name | BDBM50134800 |
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| Synonyms: | (E)-N-Hydroxy-3-[1-methyl-4-((E)-3-oxo-3-o-tolyl-propenyl)-1H-pyrrol-2-yl]-acrylamide | (E)-N-Hydroxy-3-[1-methyl-4-(3-oxo-3-o-tolyl-propenyl)-1H-pyrrol-2-yl]-acrylamide | CHEMBL145116 | N-hydroxy-3-(1-methyl-4-(3-oxo-3-o-tolylprop-1-enyl)-1H-pyrrol-2-yl)acrylamide |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18N2O3 |
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| Mol. Mass. | 310.3471 |
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| SMILES | Cc1ccccc1C(=O)C=Cc1cc(C=CC(=O)NO)n(C)c1 |w:10.11,14.14| |
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| Structure | 
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