| Reaction Details |
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 | Report a problem with these data |
| Target | 72 kDa type IV collagenase |
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| Ligand | BDBM50166249 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_305379 (CHEMBL832894) |
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| IC50 | 86±n/a nM |
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| Citation |  Breyholz, HJ; Schäfers, M; Wagner, S; Höltke, C; Faust, A; Rabeneck, H; Levkau, B; Schober, O; Kopka, K C-5-disubstituted barbiturates as potential molecular probes for noninvasive matrix metalloproteinase imaging. J Med Chem48:3400-9 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 72 kDa type IV collagenase |
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| Name: | 72 kDa type IV collagenase |
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| Synonyms: | 72 kDa gelatinase | 72 kDa type IV collagenase precursor | CLG4A | Gelatinase A | Gelatinase A (MMP-2) | MMP2 | MMP2_HUMAN | Matrix metalloproteinase-2 | Matrix metalloproteinase-2 (MMP 2) | Matrix metalloproteinase-2 (MMP2) | Matrix metalloproteinases 2 (MMP-2) | TBE-1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 73870.36 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08253 |
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| Residue: | 660 |
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| Sequence: | MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAVQYLNTFYGC
PKESCNLFVLKDTLKKMQKFFGLPQTGDLDQNTIETMRKPRCGNPDVANYNFFPRKPKWD
KNQITYRIIGYTPDLDPETVDDAFARAFQVWSDVTPLRFSRIHDGEADIMINFGRWEHGD
GYPFDGKDGLLAHAFAPGTGVGGDSHFDDDELWTLGEGQVVRVKYGNADGEYCKFPFLFN
GKEYNSCTDTGRSDGFLWCSTTYNFEKDGKYGFCPHEALFTMGGNAEGQPCKFPFRFQGT
SYDSCTTEGRTDGYRWCGTTEDYDRDKKYGFCPETAMSTVGGNSEGAPCVFPFTFLGNKY
ESCTSAGRSDGKMWCATTANYDDDRKWGFCPDQGYSLFLVAAHEFGHAMGLEHSQDPGAL
MAPIYTYTKNFRLSQDDIKGIQELYGASPDIDLGTGPTPTLGPVTPEICKQDIVFDGIAQ
IRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAPQEEKAVFFAGNEY
WIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRYNEVKKKMDP
GFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAYYLKLENQSLKSVKFGSIKSDWLGC
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| BDBM50166249 |
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| n/a |
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| Name | BDBM50166249 |
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| Synonyms: | 5-[4-(4-Bromo-phenoxy)-phenyl]-5-[4-(4-iodo-phenyl)-piperazin-1-yl]-pyrimidine-2,4,6-trione | CHEMBL372914 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H22BrIN4O4 |
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| Mol. Mass. | 661.286 |
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| SMILES | Brc1ccc(Oc2ccc(cc2)C2(N3CCN(CC3)c3ccc(I)cc3)C(=O)NC(=O)NC2=O)cc1 |
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| Structure | 
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