Reaction Details |
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Target | Progesterone receptor |
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Ligand | BDBM50172036 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_321436 (CHEMBL880244) |
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IC50 | 85±n/a nM |
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Citation | Betageri, R; Zhang, Y; Zindell, RM; Kuzmich, D; Kirrane, TM; Bentzien, J; Cardozo, M; Capolino, AJ; Fadra, TN; Nelson, RM; Paw, Z; Shih, DT; Shih, CK; Zuvela-Jelaska, L; Nabozny, G; Thomson, DS Trifluoromethyl group as a pharmacophore: effect of replacing a CF3 group on binding and agonist activity of a glucocorticoid receptor ligand. Bioorg Med Chem Lett15:4761-9 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Progesterone receptor |
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Name: | Progesterone receptor |
Synonyms: | NR3C3 | Nuclear receptor subfamily 3 group C member 3 | PGR | PR | PRGR_HUMAN | progesterone |
Type: | Protein |
Mol. Mass.: | 98979.52 |
Organism: | Homo sapiens (Human) |
Description: | P06401 |
Residue: | 933 |
Sequence: | MTELKAKGPRAPHVAGGPPSPEVGSPLLCRPAAGPFPGSQTSDTLPEVSAIPISLDGLLF
PRPCQGQDPSDEKTQDQQSLSDVEGAYSRAEATRGAGGSSSSPPEKDSGLLDSVLDTLLA
PSGPGQSQPSPPACEVTSSWCLFGPELPEDPPAAPATQRVLSPLMSRSGCKVGDSSGTAA
AHKVLPRGLSPARQLLLPASESPHWSGAPVKPSPQAAAVEVEEEDGSESEESAGPLLKGK
PRALGGAAAGGGAAAVPPGAAAGGVALVPKEDSRFSAPRVALVEQDAPMAPGRSPLATTV
MDFIHVPILPLNHALLAARTRQLLEDESYDGGAGAASAFAPPRSSPCASSTPVAVGDFPD
CAYPPDAEPKDDAYPLYSDFQPPALKIKEEEEGAEASARSPRSYLVAGANPAAFPDFPLG
PPPPLPPRATPSRPGEAAVTAAPASASVSSASSSGSTLECILYKAEGAPPQQGPFAPPPC
KAPGASGCLLPRDGLPSTSASAAAAGAAPALYPALGLNGLPQLGYQAAVLKEGLPQVYPP
YLNYLRPDSEASQSPQYSFESLPQKICLICGDEASGCHYGVLTCGSCKVFFKRAMEGQHN
YLCAGRNDCIVDKIRRKNCPACRLRKCCQAGMVLGGRKFKKFNKVRVVRALDAVALPQPV
GVPNESQALSQRFTFSPGQDIQLIPPLINLLMSIEPDVIYAGHDNTKPDTSSSLLTSLNQ
LGERQLLSVVKWSKSLPGFRNLHIDDQITLIQYSWMSLMVFGLGWRSYKHVSGQMLYFAP
DLILNEQRMKESSFYSLCLTMWQIPQEFVKLQVSQEEFLCMKVLLLLNTIPLEGLRSQTQ
FEEMRSSYIRELIKAIGLRQKGVVSSSQRFYQLTKLLDNLHDLVKQLHLYCLNTFIQSRA
LSVEFPEMMSEVIAAQLPKILAGMVKPLLFHKK
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BDBM50172036 |
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n/a |
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Name | BDBM50172036 |
Synonyms: | 4-(5-Fluoro-2-methoxy-phenyl)-2-hydroxy-4-methyl-2-trifluoromethyl-pentanoic acid (1-oxo-1,3-dihydro-isobenzofuran-5-yl)-amide | CHEMBL194812 |
Type | Small organic molecule |
Emp. Form. | C22H21F4NO5 |
Mol. Mass. | 455.3995 |
SMILES | COc1ccc(F)cc1C(C)(C)CC(O)(C(=O)Nc1ccc2C(=O)OCc2c1)C(F)(F)F |
Structure |
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