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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | DNA polymerase catalytic subunit | ||
| Ligand | BDBM50090910 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | ChEMBL_321600 (CHEMBL872297) | ||
| pH | 7.5±n/a | ||
| IC50 | 600±n/a nM | ||
| Comments | extracted | ||
| Citation |  Schnute, ME; Cudahy, MM; Brideau, RJ; Homa, FL; Hopkins, TA; Knechtel, ML; Oien, NL; Pitts, TW; Poorman, RA; Wathen, MW; Wieber, JL 4-Oxo-4,7-dihydrothieno[2,3-b]pyridines as non-nucleoside inhibitors of human cytomegalovirus and related herpesvirus polymerases. J Med Chem48:5794-804 (2005) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| DNA polymerase catalytic subunit | |||
| Name: | DNA polymerase catalytic subunit | ||
| Synonyms: | DNA polymerase | DPOL_VZVD | ||
| Type: | PROTEIN | ||
| Mol. Mass.: | 134062.58 | ||
| Organism: | Varicella-zoster virus (strain Dumas) (HHV-3) (Human herpesvirus 3) | ||
| Description: | ChEMBL_321600 | ||
| Residue: | 1194 | ||
| Sequence: |
| ||
| BDBM50090910 | |||
| n/a | |||
| Name | BDBM50090910 | ||
| Synonyms: | 3alpha,16,17,18-tetrahydroxyaphidicolone | 6,13-di(hydroxymethyl)-2,6-dimethyl-(1S,2S,5R,6R,7R)-tetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol | 6,13-di(hydroxymethyl)-2,6-dimethyl-(1S,2S,5R,6R,7R,10S,12R,13R)-tetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol (Aphidicolin) | 6,13-di(hydroxymethyl)-2,6-dimethyl-(1S,2S,5R,6R,7R,10S,12R,13R)-tetracyclo[10.3.1.01,10.02,7]hexadecane-5,13-diol(Aphidicolin) | CHEMBL29711 | aphidicholin | aphidicolin | cid_457964 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C20H34O4 | ||
| Mol. Mass. | 338.4816 | ||
| SMILES | C[C@@]1(CO)[C@H](O)CC[C@@]2(C)[C@H]1CC[C@H]1C[C@@H]3C[C@]21CC[C@]3(O)CO |r| | ||
| Structure | 
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