Reaction Details |
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Target | DNA polymerase III PolC-type |
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Ligand | BDBM50176101 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_320983 (CHEMBL872130) |
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Ki | 35±n/a nM |
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Citation | Zhi, C; Long, ZY; Manikowski, A; Brown, NC; Tarantino, PM; Holm, K; Dix, EJ; Wright, GE; Foster, KA; Butler, MM; LaMarr, WA; Skow, DJ; Motorina, I; Lamothe, S; Storer, R Synthesis and antibacterial activity of 3-substituted-6-(3-ethyl-4-methylanilino)uracils. J Med Chem48:7063-74 (2005) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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DNA polymerase III PolC-type |
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Name: | DNA polymerase III PolC-type |
Synonyms: | DNA polymerase III | DNA polymerase IIIC | DNA-directed DNA polymerase | DPO3_BACSU | PolIII | dnaF | mutI | polC |
Type: | Enzyme |
Mol. Mass.: | 162625.67 |
Organism: | Bacillus subtilis |
Description: | Enzyme was purified from recombinant strains. |
Residue: | 1437 |
Sequence: | MEQLSVNRRQFQILLQQINMTDDTFMTYFEHGEIKKLTIHKASKSWHFHFQFKSLLPFQI
YDTLTTRLTQSFAHIAKVTSSIEVQDAEVSESIVQDYWSRCIEELQGISPPIISLLNQQK
PKLKGNKLIVKTKTDTEAAALKNKYSSMIQAEYRQFGFPDLQLDAEIFVSEQEVQKFREQ
KLAEDQERAMQALIEMEKKDKESDEDQAPSGPLVIGYQIKDNEEIRTLDSIMDEERRITV
QGYVFDVETRELKSGRTLCIFKITDYTNSILIKMFAREKEDAALMKSLKKGMWVKARGSI
QNDTFVRDLVMIANDVNEIKAKTREDSAPEGEKRVELHLHSPMSQMDAVTGIGKLVEQAK
KWGHEAIALTDHAVVQSFPDAYSAAKKHGIKMIYGMEANLVDDGVPIAYNAAHRLLEEET
YVVFDVETTGLSAVYDTIIELAAVKVKGGEIIDKFEAFANPHRPLSATIIELTGITDDML
QDAPDVVDVIRDFREWIGDDILVAHNASFDMGFLNVAYKKLLEVEKAKNPVIDTLELGRF
LYPEFKNHRLNTLCKKFDIELTQHHRAIYDTEATAYLLLKMLKDAAEKGIQYHDELNENM
GQSNAYQRSRPYHATLLAVNSTGLKNLFKLVSLSHIHYFYRVPRIPRSQLEKYREGLLIG
SACDRGEVFEGMMQKSPEEVEDIASFYDYLEVQPPEVYRHLLELELVRDEKALKEIIANI
TKLGEKLNKPVVATGNVHYLNDEDKIYRKILISSQGGANPLNRHELPKVHFRTTDEMLEA
FSFLGEEKAKEIVVTNTQKVASLVDDIKPIKDDLYTPKIEGADEEIREMSYQRARSIYGE
ELPEIVEARIEKELKSIIGHGFAVIYLISHKLVKRSLDDGYLVGSRGSVGSSLVATLTEI
TEVNPLPPHYVCPECQHSEFFNDGSVGSGFDLPDKTCPHCGTPLKKDGHDIPFETFLGFK
GDKVPDIDLNFSGEYQPQAHNYTKVLFGEDNVYRAGTIGTVAEKTAYGYVKGYAGDNNLH
MRGAEIDRLVQGCTGVKRTTGQHPGGIIVVPDYMDIYDFSPIQFPADATGSEWKTTHFDF
HSIHDNLLKLDILGHDDPTVIRMLQDLSGIDPKTIPTDDPEVMKIFQGTESLGVTEEQIG
CKTGTLGIPEFGTRFVRQMLEDTKPTTFSELVQISGLSHGTDVWLGNAQELIHNNICELS
EVIGCRDDIMVYLIYQGLEPSLAFKIMEFVRKGKGLTPEWEEEMKNNNVPDWYIDSCKKI
KYMFPKAHAAAYVLMAVRIAYFKVHHALLYYAAYFTVRADDFDIDTMIKGSTAIRAVMED
INAKGLDASPKEKNLLTVLELALEMCERGYSFQKVDLYRSSATEFIIDGNSLIPPFNSIP
GLGTNAALNIVKAREEGEFLSKEDLQKRGKVSKTILEYLDRHGCLESLPDQNQLSLF
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BDBM50176101 |
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n/a |
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Name | BDBM50176101 |
Synonyms: | 2-Chloro-N-{4-[4-(3-ethyl-4-methyl-phenylamino)-2,6-dioxo-3,6-dihydro-2H-pyrimidin-1-yl]-butyl}-acetamide | CHEMBL198979 |
Type | Small organic molecule |
Emp. Form. | C19H25ClN4O3 |
Mol. Mass. | 392.88 |
SMILES | CCc1cc(Nc2cc(=O)n(CCCCNC(=O)CCl)c(=O)[nH]2)ccc1C |
Structure |
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