| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate receptor ionotropic, kainate 1 |
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| Ligand | BDBM50178145 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_326521 (CHEMBL862719) |
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| Kd | 209±n/a nM |
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| Citation |  Dolman, NP; Troop, HM; More, JC; Alt, A; Knauss, JL; Nistico, R; Jack, S; Morley, RM; Bortolotto, ZA; Roberts, PJ; Bleakman, D; Collingridge, GL; Jane, DE Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. J Med Chem48:7867-81 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate receptor ionotropic, kainate 1 |
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| Name: | Glutamate receptor ionotropic, kainate 1 |
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| Synonyms: | GRIK1_RAT | Glur5 | Glutamate receptor ionotropic kainate 1 | Glutamate receptor ionotropic, kainate | Glutamate receptor, ionotropic kainate 1 | Glutamate-Kainate | Grik1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 107860.82 |
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| Organism: | RAT |
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| Description: | P22756 |
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| Residue: | 949 |
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| Sequence: | MERSTVLIQPGLWTRDTSWTLLYFLCYILPQTSPQVLRIGGIFETVENEPVNVEELAFKF
AVTSINRNRTLMPNTTLTYDIQRINLFDSFEASRRACDQLALGVAALFGPSHSSSVSAVQ
SICNALEVPHIQTRWKHPSVDSRDLFYINLYPDYAAISRAVLDLVLYYNWKTVTVVYEDS
TGLIRLQELIKAPSRYNIKIKIRQLPPANKDAKPLLKEMKKSKEFYVIFDCSHETAAEIL
KQILFMGMMTEYYHYFFTTLDLFALDLELYRYSGVNMTGFRKLNIDNPHVSSIIEKWSME
RLQAPPRPETGLLDGMMTTEAALMYDAVYMVAIASHRASQLTVSSLQCHRHKPCALGPRF
MNLIKEARWDGLTGRITFNKTDGLRKDFDLDIISLKEEGTEKASGEVSKHLYKVWKKIGI
WNSNSGLNMTDGNRDRSNNITDSLANRTLIVTTILEEPYVMYRKSDKPLYGNDRFEAYCL
DLLKELSNILGFLYDVKLVPDGKYGAQNDKGEWNGMVKELIDHRADLAVAPLTITYVREK
VIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLSPDIWMYVLLACLGVSCVLFVIARFT
PYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTL
IIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVRDGSTMTFFKKSKISTYEKM
WAFMSSRQQSALVKNSDEGIQRVLTTDYALLMESTSIEYVTQRNCNLTQIGGLIDSKGYG
VGTPIGSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEDSKEASALGVENIGGIFI
VLAAGLVLSVFVAIGEFLYKSRKNNDVEQKGKSSRLRFYFRNKVRFHGSKKESLGVEKCL
SFNAIMEELGISLKNQKKLKKKSRTKGKSSFTSILTCHQRRTQRKETVA
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| BDBM50178145 |
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| n/a |
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| Name | BDBM50178145 |
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| Synonyms: | (S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl)-5-iodopyrimidine-2,4-dione | (S)-2-((3-(2-amino-2-carboxyethyl)-5-iodo-2,6-dioxo-2,3-dihydropyrimidin-1(6H)-yl)methyl)benzoic acid | CHEMBL427186 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H14IN3O6 |
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| Mol. Mass. | 459.1926 |
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| SMILES | N[C@@H](Cn1cc(I)c(=O)n(Cc2ccccc2C(O)=O)c1=O)C(O)=O |
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| Structure | 
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