| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Glutamate receptor ionotropic, kainate 2 |
|---|
| Ligand | BDBM50178148 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_326525 (CHEMBL862730) |
|---|
| Ki | >1000000±n/a nM |
|---|
| Citation |  Dolman, NP; Troop, HM; More, JC; Alt, A; Knauss, JL; Nistico, R; Jack, S; Morley, RM; Bortolotto, ZA; Roberts, PJ; Bleakman, D; Collingridge, GL; Jane, DE Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. J Med Chem48:7867-81 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Glutamate receptor ionotropic, kainate 2 |
|---|
| Name: | Glutamate receptor ionotropic, kainate 2 |
|---|
| Synonyms: | GRIK2_RAT | Glur6 | Glutamate receptor ionotropic kainate 2 | Grik2 | Ionotropic glutamate receptor kainate 2/5 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 102478.61 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_936439 |
|---|
| Residue: | 908 |
|---|
| Sequence: | MKIISPVLSNLVFSRSIKVLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFA
VNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQS
ICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST
GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILK
QALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMER
LQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRHKPWRFGTRFM
SLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK
PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEI
RLVEDGKYGAQDDVNGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISI
LYRKPNGTNPGVFSFLNPLSPDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSD
VVENNFTLLNSFWFGVGALMQQGSELMPKALSTRIVGGIWWFFTLIIISSYTANLAAFLT
VERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKISTYDKMWAFMSSRRQSVLVKS
NEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPMGSPYRDKITI
AILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG
EFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRR
LPGKETMA
|
|
|
|---|
| BDBM50178148 |
|---|
| n/a |
|---|
| Name | BDBM50178148 |
|---|
| Synonyms: | (RS)-1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione | CHEMBL372631 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C15H15N3O6 |
|---|
| Mol. Mass. | 333.2961 |
|---|
| SMILES | NC(Cn1ccc(=O)n(Cc2ccccc2C(O)=O)c1=O)C(O)=O |
|---|
| Structure | 
|
|---|
Search and Browse
