| Reaction Details |
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 | Report a problem with these data |
| Target | Glutamate receptor ionotropic, kainate 3 |
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| Ligand | BDBM50178148 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_326526 (CHEMBL862731) |
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| IC50 | 880000±n/a nM |
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| Citation |  Dolman, NP; Troop, HM; More, JC; Alt, A; Knauss, JL; Nistico, R; Jack, S; Morley, RM; Bortolotto, ZA; Roberts, PJ; Bleakman, D; Collingridge, GL; Jane, DE Synthesis and pharmacology of willardiine derivatives acting as antagonists of kainate receptors. J Med Chem48:7867-81 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Glutamate receptor ionotropic, kainate 3 |
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| Name: | Glutamate receptor ionotropic, kainate 3 |
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| Synonyms: | EAA5 | Excitatory amino acid receptor 5 | GLUR7 | GRIK3 | GRIK3_HUMAN | GluR-7 | Glutamate receptor 7 | Glutamate receptor ionotropic kainate | Glutamate receptor ionotropic kainate 3 | Glutamate receptor, ionotropic kainate 3 | Glutamate-Kainate 7 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 104046.44 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Glutamate-Kainate 7 0 HUMAN::Q13003 |
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| Residue: | 919 |
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| Sequence: | MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAF
RFSANIINRNRTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNA
VQSICNALEVPHIQLRWKHHPLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYD
DSTGLIRLQELIMAPSRYNIRLKIRQLPIDSDDSRPLLKEMKRGREFRIIFDCSHTMAAQ
ILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLTGFRILNVDNPHVSAIVEKWS
MERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQCHRHKAWRFGG
RFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVA
KGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFS
YEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGV
SILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPG
SEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAF
LTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVK
NNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKIT
IAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAV
GEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDR
RLPGKDSMACSTSLAPVFP
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| BDBM50178148 |
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| n/a |
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| Name | BDBM50178148 |
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| Synonyms: | (RS)-1-(2-amino-2-carboxyethyl)-3-(2-carboxybenzyl)pyrimidine-2,4-dione | CHEMBL372631 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H15N3O6 |
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| Mol. Mass. | 333.2961 |
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| SMILES | NC(Cn1ccc(=O)n(Cc2ccccc2C(O)=O)c1=O)C(O)=O |
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| Structure | 
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