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Target3-oxoacyl-[acyl-carrier-protein] synthase 1
LigandBDBM50134355
Substrate/Competitorn/a
Meas. Tech.ChEMBL_330089
IC50>1000000±n/a nM
Citation Kim PZhang YMShenoy GNguyen QABoshoff HIManjunatha UHGoodwin MBLonsdale JPrice ACMiller DJDuncan KWhite SWRock COBarry CEDowd CS Structure-activity relationships at the 5-position of thiolactomycin: an intact (5R)-isoprene unit is required for activity against the condensing enzymes from Mycobacterium tuberculosis and Escherichia coli. J Med Chem 49:159-71 (2006) [PubMed]  Article
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3-oxoacyl-[acyl-carrier-protein] synthase 1
Name:3-oxoacyl-[acyl-carrier-protein] synthase 1
Synonyms:n/a
Type:PROTEIN
Mol. Mass.:42605.82
Organism:Escherichia coli (strain K12)
Description:ChEMBL_330089
Residue:406
Sequence:
MKRAVITGLGIVSSIGNNQQEVLASLREGRSGITFSQELKDSGMRSHVWGNVKLDTTGLI
DRKVVRFMSDASIYAFLSMEQAIADAGLSPEAYQNNPRVGLIAGSGGGSPRFQVFGADAM
RGPRGLKAVGPYVVTKAMASGVSACLATPFKIHGVNYSISSACATSAHCIGNAVEQIQLG
KQDIVFAGGGEELCWEMACEFDAMGALSTKYNDTPEKASRTYDAHRDGFVIAGGGGMVVV
EELEHALARGAHIYAEIVGYGATSDGADMVAPSGEGAVRCMKMAMHGVDTPIDYLNSHGT
STPVGDVKELAAIREVFGDKSPAISATKAMTGHSLGAAGVQEAIYSLLMLEHGFIAPSIN
IEELDEQAAGLNIVTETTDRELTTVMSNSFGFGGTNATLVMRKLKD
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  Blast E-value cutoff:
BDBM50134355
n/a
NameBDBM50134355
Synonyms:5-(4-tert-Butyl-benzyl)-4-hydroxy-3,5-dimethyl-5H-thiophen-2-one | 5-(4-tert-butylbenzyl)-3,5-dimethyl-4-hydroxy-5H-thiophen-2-one | CHEMBL333571
TypeSmall organic molecule
Emp. Form.C17H22O2S
Mol. Mass.290.42
SMILESCC1C(=O)SC(C)(Cc2ccc(cc2)C(C)(C)C)C1=O
Structure
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