| Reaction Details |
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 | Report a problem with these data |
| Target | Carbonic anhydrase |
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| Ligand | BDBM10887 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_347177 (CHEMBL862664) |
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| Ki | 205±n/a nM |
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| Citation |  Nishimori, I; Vullo, D; Minakuchi, T; Morimoto, K; Onishi, S; Scozzafava, A; Supuran, CT Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori. Bioorg Med Chem Lett16:2182-8 (2006) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carbonic anhydrase |
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| Name: | Carbonic anhydrase |
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| Synonyms: | Beta-carbonic anhydrase | CYNT_HELPY | Carbonic anhydrase 1 | cynT | hpβCA |
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| Type: | Protein |
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| Mol. Mass.: | 25517.77 |
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| Organism: | Helicobacter pylori (strain G27) |
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| Description: | O24855 |
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| Residue: | 221 |
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| Sequence: | MKAFLGALEFQENEYEELKELYESLKTKQKPHTLFISCVDSRVVPNLITGTKPGELYVIC
NMGNVNPPKTSYKESLSTIASIEYAIAHVGVQNLIICGHSDCGACGSVHLIHDETTKAKT
PYIANWIQFLEPVKEELKNHPQFSNHFAKRSWLTERLNARLQLNNLLSYDFIQEKASKNE
LKIFGWHYIIETGRIYNYNFESHFFEPIGETIKQRKSHENF
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| BDBM10887 |
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| n/a |
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| Name | BDBM10887 |
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| Synonyms: | Sulfamate 7 | Topiramate (TPM) | US11535599, Example topiramate | [(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.0^{2,6}]dodecan-6-yl]methyl sulfamate |
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| Type | Small organic molecule |
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| Emp. Form. | C12H21NO8S |
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| Mol. Mass. | 339.362 |
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| SMILES | CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1 |r| |
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| Structure | 
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