| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Extracellular calcium-sensing receptor |
|---|
| Ligand | BDBM50193410 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_382280 (CHEMBL866784) |
|---|
| IC50 | 250±n/a nM |
|---|
| Citation |  Kessler, A; Faure, H; Petrel, C; Rognan, D; Césario, M; Ruat, M; Dauban, P; Dodd, RH N1-Benzoyl-N2-[1-(1-naphthyl)ethyl]-trans-1,2-diaminocyclohexanes: Development of 4-chlorophenylcarboxamide (calhex 231) as a new calcium sensing receptor ligand demonstrating potent calcilytic activity. J Med Chem49:5119-28 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Extracellular calcium-sensing receptor |
|---|
| Name: | Extracellular calcium-sensing receptor |
|---|
| Synonyms: | CASR_RAT | Calcium sensing receptor | Casr | Gprc2a | Parathyroid Cell calcium-sensing receptor | Pcar1 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 120858.46 |
|---|
| Organism: | Rattus norvegicus |
|---|
| Description: | ChEMBL_750426 |
|---|
| Residue: | 1079 |
|---|
| Sequence: | MASYSCCLALLALAWHSSAYGPDQRAQKKGDIILGGLFPIHFGVAAKDQDLKSRPESVEC
IRYNFRGFRWLQAMIFAIEEINSSPSLLPNMTLGYRIFDTCNTVSKALEATLSFVAQNKI
DSLNLDEFCNCSEHIPSTIAVVGATGSGVSTAVANLLGLFYIPQVSYASSSRLLSNKNQY
KSFLRTIPNDEHQATAMADIIEYFRWNWVGTIAADDDYGRPGIEKFREEAEERDICIDFS
ELISQYSDEEEIQQVVEVIQNSTAKVIVVFSSGPDLEPLIKEIVRRNITGRIWLASEAWA
SSSLIAMPEYFHVVGGTIGFGLKAGQIPGFREFLQKVHPRKSVHNGFAKEFWEETFNCHL
QEGAKGPLPVDTFVRSHEEGGNRLLNSSTAFRPLCTGDENINSVETPYMDYEHLRISYNV
YLAVYSIAHALQDIYTCLPGRGLFTNGSCADIKKVEAWQVLKHLRHLNFTNNMGEQVTFD
ECGDLVGNYSIINWHLSPEDGSIVFKEVGYYNVYAKKGERLFINEEKILWSGFSREVPFS
NCSRDCQAGTRKGIIEGEPTCCFECVECPDGEYSGETDASACDKCPDDFWSNENHTSCIA
KEIEFLAWTEPFGIALTLFAVLGIFLTAFVLGVFIKFRNTPIVKATNRELSYLLLFSLLC
CFSSSLFFIGEPQDWTCRLRQPAFGISFVLCISCILVKTNRVLLVFEAKIPTSFHRKWWG
LNLQFLLVFLCTFMQILICIIWLYTAPPSSYRNHELEDEIIFITCHEGSLMALGSLIGYT
CLLAAICFFFAFKSRKLPENFNEAKFITFSMLIFFIVWISFIPAYASTYGKFVSAVEVIA
ILAASFGLLACIFFNKVYIILFKPSRNTIEEVRSSTAAHAFKVAARATLRRPNISRKRSS
SLGGSTGSIPSSSISSKSNSEDRFPQPERQKQQQPLSLTQQEQQQQPLTLHPQQQQQPQQ
PRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSMRQNSLEAQRSNDTLGRHQALLPLQCA
DADSEMTIQETGLQGPMVGDHQPEMESSDEMSPALVMSTSRSFVISGGGSSVTENVLHS
|
|
|
|---|
| BDBM50193410 |
|---|
| n/a |
|---|
| Name | BDBM50193410 |
|---|
| Synonyms: | CHEMBL536975 | N-[(1S,2S)-2-((R)-1-naphthalen-1-yl-ethylamino)-cyclohexyl]-4-trifluoromethoxy-benzamide hydrochloride |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H27F3N2O2 |
|---|
| Mol. Mass. | 456.5 |
|---|
| SMILES | C[C@@H](N[C@H]1CCCC[C@@H]1NC(=O)c1ccc(OC(F)(F)F)cc1)c1cccc2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
