| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Alpha-1B adrenergic receptor |
|---|
| Ligand | BDBM50187754 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_384613 (CHEMBL866127) |
|---|
| Ki | 14±n/a nM |
|---|
| Citation |  Hayashi, R; Ohmori, E; Isogaya, M; Moriwaki, M; Kumagai, H Design and synthesis of selective alpha1B adrenoceptor antagonists. Bioorg Med Chem Lett16:4045-7 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Alpha-1B adrenergic receptor |
|---|
| Name: | Alpha-1B adrenergic receptor |
|---|
| Synonyms: | ADA1B_RAT | Adra1b | Alpha 1B-adrenoceptor | Alpha 1B-adrenoreceptor | Alpha adrenergic receptor 1A and 1B | Alpha-1 Adrenergic Receptor | Alpha-1Adrenoceptor | Alpha-1B adrenergic receptor | Alpha-1B adrenoreceptor | adrenergic Alpha1B |
|---|
| Type: | G Protein-Coupled Receptor (GPCR) |
|---|
| Mol. Mass.: | 56606.71 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | Receptor binding assays were performed using rat cortical membranes. |
|---|
| Residue: | 515 |
|---|
| Sequence: | MNPDLDTGHNTSAPAHWGELKDDNFTGPNQTSSNSTLPQLDVTRAISVGLVLGAFILFAI
VGNILVILSVACNRHLRTPTNYFIVNLAIADLLLSFTVLPFSATLEVLGYWVLGRIFCDI
WAAVDVLCCTASILSLCAISIDRYIGVRYSLQYPTLVTRRKAILALLSVWVLSTVISIGP
LLGWKEPAPNDDKECGVTEEPFYALFSSLGSFYIPLAVILVMYCRVYIVAKRTTKNLEAG
VMKEMSNSKELTLRIHSKNFHEDTLSSTKAKGHNPRSSIAVKLFKFSREKKAAKTLGIVV
GMFILCWLPFFIALPLGSLFSTLKPPDAVFKVVFWLGYFNSCLNPIIYPCSSKEFKRAFM
RILGCQCRGGRRRRRRRRLGACAYTYRPWTRGGSLERSQSRKDSLDDSGSCMSGTQRTLP
SASPSPGYLGRGTQPPVELCAFPEWKPGALLSLPEPPGRRGRLDSGPLFTFKLLGDPESP
GTEGDTSNGGCDTTTDLANGQPGFKSNMPLAPGHF
|
|
|
|---|
| BDBM50187754 |
|---|
| n/a |
|---|
| Name | BDBM50187754 |
|---|
| Synonyms: | 3-(1-(3-(piperidin-1-yl)propyl)piperidin-4-yl)benzo[d]isoxazole dihydrochloride | CHEMBL534943 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H29N3O |
|---|
| Mol. Mass. | 327.4638 |
|---|
| SMILES | C(CN1CCCCC1)CN1CCC(CC1)c1noc2ccccc12 |
|---|
| Structure | 
|
|---|
Search and Browse
