Ki Summary

Reaction Details

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Target

Adenosine receptor A3

Ligand

BDBM50202575

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_423826 (CHEMBL911267)

25±n/a nM

Citation

Baraldi, PG; Preti, D; Tabrizi, MA; Fruttarolo, F; Romagnoli, R; Carrion, MD; Cara, LC; Moorman, AR; Varani, K; Borea, PA Synthesis and biological evaluation of novel 1-deoxy-1-[6-[((hetero)arylcarbonyl)hydrazino]- 9H-purin-9-yl]-N-ethyl-beta-D-ribofuranuronamide derivatives as useful templates for the development of A2B adenosine receptor agonists. J Med Chem50:374-80 (2007) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Adenosine receptor A3

Name:

Adenosine receptor A3

Synonyms:

A3 adenosine receptor (hA3) | AA3R_HUMAN | ADORA3 | Adenosine A3 receptor (A3AR)

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

36197.32

Organism:

Homo sapiens (Human)

Description:

P0DMS8

Residue:

318

Sequence:

MPNNSTALSLANVTYITMEIFIGLCAIVGNVLVICVVKLNPSLQTTTFYFIVSLALADIA
VGVLVMPLAIVVSLGITIHFYSCLFMTCLLLIFTHASIMSLLAIAVDRYLRVKLTVRYKR
VTTHRRIWLALGLCWLVSFLVGLTPMFGWNMKLTSEYHRNVTFLSCQFVSVMRMDYMVYF
SFLTWIFIPLVVMCAIYLDIFYIIRNKLSLNLSNSKETGAFYGREFKTAKSLFLVLFLFA
LSWLPLSIINCIIYFNGEVPQLVLYMGILLSHANSMMNPIVYAYKIKKFKETYLLILKAC
VVCHPSDSLDTSIEKNSE

BDBM50202575

n/a

Name

BDBM50202575

Synonyms:

1-deoxy-1-{2-chloro-6-[N'-(2-thiophen-2-yl-acetyl)-hydrazino]-9H-purin-9-yl}-N-ethyl-beta-D-ribofuranuronamide | CHEMBL217952 | N'-(2-chloro-9-((2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-tetrahydrofuran-2-yl)-9H-purin-6-yl)-2-(thiophen-2-yl)acetohydrazide

Type

Small organic molecule

Emp. Form.

C18H20ClN7O5S

Mol. Mass.

481.913

SMILES

CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(NNC(=O)Cc3cccs3)nc(Cl)nc12 |r|

Structure