Reaction Details |
| Report a problem with these data |
Target | Liver carboxylesterase 1 |
---|
Ligand | BDBM50204522 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_428057 (CHEMBL914371) |
---|
IC50 | 2000±n/a nM |
---|
Citation | Romero, FA; Du, W; Hwang, I; Rayl, TJ; Kimball, FS; Leung, D; Hoover, HS; Apodaca, RL; Breitenbucher, JG; Cravatt, BF; Boger, DL Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase. J Med Chem50:1058-68 (2007) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Liver carboxylesterase 1 |
---|
Name: | Liver carboxylesterase 1 |
Synonyms: | Acyl coenzyme A:cholesterol acyltransferase | Acyl-CoA: cholesterol acyltransferase (ACAT) | CES1 | CES2 | EST1_HUMAN | SES1 | Serine hydrolase (CES1) |
Type: | Protein |
Mol. Mass.: | 62520.83 |
Organism: | Homo sapiens (Human) |
Description: | n/a |
Residue: | 567 |
Sequence: | MWLRAFILATLSASAAWGHPSSPPVVDTVHGKVLGKFVSLEGFAQPVAIFLGIPFAKPPL
GPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENIPLKLSEDCLYLN
IYTPADLTKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQYRLGIWGFFST
GDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLF
HRAISESGVALTSVLVKKGDVKPLAEQIAITAGCKTTTSAVMVHCLRQKTEEELLETTLK
MKFLSLDLQGDPRESQPLLGTVIDGMLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIP
MQLMSYPLSEGQLDQKTAMSLLWKSYPLVCIAKELIPEATEKYLGGTDDTVKKKDLFLDL
IADVMFGVPSVIVARNHRDAGAPTYMYEFQYRPSFSSDMKPKTVIGDHGDELFSVFGAPF
LKEGASEEEIRLSKMVMKFWANFARNGNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLK
DKEVAFWTNLFAKKAVEKPPQTEHIEL
|
|
|
BDBM50204522 |
---|
n/a |
---|
Name | BDBM50204522 |
Synonyms: | 7-phenyl-1-(5-(4-(trifluoromethyl)pyridin-2-yl)oxazol-2-yl)heptan-1-one | CHEMBL220556 |
Type | Small organic molecule |
Emp. Form. | C22H21F3N2O2 |
Mol. Mass. | 402.4095 |
SMILES | FC(F)(F)c1ccnc(c1)-c1cnc(o1)C(=O)CCCCCCc1ccccc1 |
Structure |
|