| Reaction Details |
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 | Report a problem with these data |
| Target | Neutral cholesterol ester hydrolase 1 |
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| Ligand | BDBM50204527 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_428056 (CHEMBL914788) |
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| IC50 | >100000±n/a nM |
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| Citation |  Romero, FA; Du, W; Hwang, I; Rayl, TJ; Kimball, FS; Leung, D; Hoover, HS; Apodaca, RL; Breitenbucher, JG; Cravatt, BF; Boger, DL Potent and selective alpha-ketoheterocycle-based inhibitors of the anandamide and oleamide catabolizing enzyme, fatty acid amide hydrolase. J Med Chem50:1058-68 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutral cholesterol ester hydrolase 1 |
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| Name: | Neutral cholesterol ester hydrolase 1 |
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| Synonyms: | AADACL1 | KIAA1363 | NCEH1 | NCEH1_HUMAN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 45810.81 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_835312 |
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| Residue: | 408 |
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| Sequence: | MRSSCVLLTALVALAAYYVYIPLPGSVSDPWKLMLLDATFRGAQQVSNLIHYLGLSHHLL
ALNFIIVSFGKKSAWSSAQVKVTDTDFDGVEVRVFEGPPKPEEPLKRSVVYIHGGGWALA
SAKIRYYDELCTAMAEELNAVIVSIEYRLVPKVYFPEQIHDVVRATKYFLKPEVLQKYMV
DPGRICISGDSAGGNLAAALGQQFTQDASLKNKLKLQALIYPVLQALDFNTPSYQQNVNT
PILPRYVMVKYWVDYFKGNYDFVQAMIVNNHTSLDVEEAAAVRARLNWTSLLPASFTKNY
KPVVQTTGNARIVQELPQLLDARSAPLIADQAVLQLLPKTYILTCEHDVLRDDGIMYAKR
LESAGVEVTLDHFEDGFHGCMIFTSWPTNFSVGIRTRNSYIKWLDQNL
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| BDBM50204527 |
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| n/a |
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| Name | BDBM50204527 |
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| Synonyms: | 6-(2-(7-phenylheptanoyl)oxazol-5-yl)pyrimidine-2,4(1H,3H)-dione | CHEMBL220687 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21N3O4 |
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| Mol. Mass. | 367.3984 |
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| SMILES | O=C(CCCCCCc1ccccc1)c1ncc(o1)-c1cc(=O)[nH]c(=O)[nH]1 |
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| Structure | 
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