| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dipeptidyl peptidase 4 |
|---|
| Ligand | BDBM50198847 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_432851 (CHEMBL915600) |
|---|
| IC50 | 10.1±n/a nM |
|---|
| Citation |  Sakashita, H; Akahoshi, F; Yoshida, T; Kitajima, H; Hayashi, Y; Ishii, S; Takashina, Y; Tsutsumiuchi, R; Ono, S Lead optimization of [(S)-gamma-(arylamino)prolyl]thiazolidine focused on gamma-substituent: Indoline compounds as potent DPP-IV inhibitors. Bioorg Med Chem15:641-55 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dipeptidyl peptidase 4 |
|---|
| Name: | Dipeptidyl peptidase 4 |
|---|
| Synonyms: | Bile canaliculus domain-specific membrane glycoprotein | CD_antigen=CD26 | Cd26 | DPP IV | DPP4_RAT | Dipeptidyl Peptidase IV (DPP-IV) | Dipeptidyl peptidase 4 | Dipeptidyl peptidase 4 (DDPIV) | Dipeptidyl peptidase 4 60 kDa soluble form | Dipeptidyl peptidase 4 membrane form | Dipeptidyl peptidase 4 soluble form | Dipeptidyl peptidase IV | Dipeptidyl peptidase IV 60 kDa soluble form | Dipeptidyl peptidase IV membrane form | Dipeptidyl peptidase IV soluble form | Dpp4 | GP110 glycoprotein | T-cell activation antigen CD26 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 88084.94 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | n/a |
|---|
| Residue: | 767 |
|---|
| Sequence: | MKTPWKVLLGLLGVAALVTIITVPVVLLNKDEAAADSRRTYTLADYLKNTFRVKSYSLRW
VSDSEYLYKQENNILLFNAEHGNSSIFLENSTFEIFGDSISDYSVSPDRLFVLLEYNYVK
QWRHSYTASYSIYDLNKRQLITEEKIPNNTQWITWSQEGHKLAYVWKNDIYVKIEPHLPS
HRITSTGKENVIFNGINDWVYEEEIFGAYSALWWSPNGTFLAYAQFNDTGVPLIEYSFYS
DESLQYPKTVWIPYPKAGAVNPTVKFFIVNTDSLSSTTTTIPMQITAPASVTTGDHYLCD
VAWVSEDRISLQWLRRIQNYSVMAICDYDKTTLVWNCPTTQEHIETSATGWCGRFRPAEP
HFTSDGSSFYKIVSDKDGYKHICQFQKDRKPEQVCTFITKGAWEVISIEALTSDYLYYIS
NEYKEMPGGRNLYKIQLTDHTNKKCLSCDLNPERCQYYSVSLSKEAKYYQLGCRGPGLPL
YTLHRSTDQKELRVLEDNSALDKMLQDVQMPSKKLDFIVLNETRFWYQMILPPHFDKSKK
YPLLIDVYAGPCSQKADAAFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINKRLG
TLEVEDQIEAARQFLKMGFVDSKRVAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRW
EYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQI
SKALVDAGVDFQAMWYTDEDHGIASSTAHQHIYSHMSHFLQQCFSLR
|
|
|
|---|
| BDBM50198847 |
|---|
| n/a |
|---|
| Name | BDBM50198847 |
|---|
| Synonyms: | 3-[(2S,4S)-4-(5-fluoro-1-indolinyl)-2-pyrrolidinylcarbonyl]-1,3-thiazolidine | CHEMBL223914 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H20FN3OS |
|---|
| Mol. Mass. | 321.413 |
|---|
| SMILES | Fc1ccc2N(CCc2c1)[C@@H]1CN[C@@H](C1)C(=O)N1CCSC1 |
|---|
| Structure | 
|
|---|
Search and Browse
