| Reaction Details |
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 | Report a problem with these data |
| Target | Adenosine receptor A1 |
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| Ligand | BDBM50205585 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_435757 (CHEMBL904111) |
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| Ki | 2.3±n/a nM |
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| Citation |  Baraldi, PG; Preti, D; Tabrizi, MA; Fruttarolo, F; Saponaro, G; Baraldi, S; Romagnoli, R; Moorman, AR; Gessi, S; Varani, K; Borea, PA N(6)-[(hetero)aryl/(cyclo)alkyl-carbamoyl-methoxy-phenyl]-(2-chloro)-5'-N-ethylcarboxamido-adenosines: the first example of adenosine-related structures with potent agonist activity at the human A(2B) adenosine receptor. Bioorg Med Chem15:2514-27 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Adenosine receptor A1 |
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| Name: | Adenosine receptor A1 |
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| Synonyms: | A1 adenosine receptor (hA1) | A1AR | AA1R_HUMAN | ADENOSINE A1 | ADORA1 | Adenosine A1 receptor (A1AR) | Adenosine A1-receptor | Adenosine receptor A1 (A1) | Adenosine receptor A1 (hA1) | Adenosine transporter (AdT) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 36520.92 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P30542 |
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| Residue: | 326 |
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| Sequence: | MPPSISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGA
LVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVT
PRRAAVAIAGCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYM
VYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALIL
FLFALSWLPLHILNCITLFCPSCHKPSILTYIAIFLTHGNSAMNPIVYAFRIQKFRVTFL
KIWNDHFRCQPAPPIDEDLPEERPDD
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| BDBM50205585 |
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| n/a |
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| Name | BDBM50205585 |
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| Synonyms: | (2S,3S,4R,5R)-N-ethyl-5-(6-(4-(2-(4-fluorophenylamino)-2-oxoethoxy)phenylamino)-9H-purin-9-yl)-3,4-dihydroxy-tetrahydrofuran-2-carboxamide | 1-deoxy-1-[6-{4-[(4-fluoro-phenylcarbamoyl)-methoxy]-phenylamino}-9H-purin-9-yl]-N-ethyl-beta-D-ribofuranuronamide | CHEMBL226194 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26FN7O6 |
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| Mol. Mass. | 551.5263 |
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| SMILES | CCNC(=O)[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c(Nc3ccc(OCC(=O)Nc4ccc(F)cc4)cc3)ncnc12 |
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| Structure | 
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