| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tyrosine-protein kinase Lyn |
|---|
| Ligand | BDBM50208748 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_443314 (CHEMBL892515) |
|---|
| IC50 | 7.6±n/a nM |
|---|
| Citation |  Horio, T; Hamasaki, T; Inoue, T; Wakayama, T; Itou, S; Naito, H; Asaki, T; Hayase, H; Niwa, T Structural factors contributing to the Abl/Lyn dual inhibitory activity of 3-substituted benzamide derivatives. Bioorg Med Chem Lett17:2712-7 (2007) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tyrosine-protein kinase Lyn |
|---|
| Name: | Tyrosine-protein kinase Lyn |
|---|
| Synonyms: | JTK8 | LYN | LYN_HUMAN | Lck/Yes-related novel protein tyrosine kinase | Tyrosine-protein kinase Lyn (LYN) | V-yes-1 Yamaguchi sarcoma viral related oncogene homolog | p53Lyn | p56Lyn |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 58575.92 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P07948 |
|---|
| Residue: | 512 |
|---|
| Sequence: | MGCIKSKGKDSLSDDGVDLKTQPVRNTERTIYVRDPTSNKQQRPVPESQLLPGQRFQTKD
PEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLLTKKEGFIPSNYVAK
LNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFDPVHGDVI
KHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQADGLCRRLEKACISPKPQKPWDKDAW
EIPRESIKLVKRLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHD
KLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIER
KNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCF
TIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCW
KEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
|
|
|
|---|
| BDBM50208748 |
|---|
| n/a |
|---|
| Name | BDBM50208748 |
|---|
| Synonyms: | (4-(((S)-3-((dimethylamino)methyl)pyrrolidin-1-yl)methyl)-3-(trifluoromethyl)phenyl)(4-methyl-3-(4-(pyrimidin-5-yl)pyrimidin-2-ylamino)phenylamino)methanol hydrochloride | CHEMBL538337 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C31H35F3N8O |
|---|
| Mol. Mass. | 592.6578 |
|---|
| SMILES | CN(C)C[C@@H]1CCN(Cc2ccc(cc2C(F)(F)F)C(O)Nc2ccc(C)c(Nc3nccc(n3)-c3cncnc3)c2)C1 |w:19.20| |
|---|
| Structure | 
|
|---|
Search and Browse
