| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine kinase |
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| Ligand | BDBM50206500 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_454746 (CHEMBL886768) |
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| IC50 | >500000±n/a nM |
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| Citation |  Ciliberti, N; Manfredini, S; Angusti, A; Durini, E; Solaroli, N; Vertuani, S; Buzzoni, L; Bonache, MC; Ben-Shalom, E; Karlsson, A; Saada, A; Balzarini, J Novel selective human mitochondrial kinase inhibitors: design, synthesis and enzymatic activity. Bioorg Med Chem15:3065-81 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidine kinase |
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| Name: | Thymidine kinase |
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| Synonyms: | KITH_HHV1 | TK | UL23 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40902.47 |
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| Organism: | Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1) |
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| Description: | ChEMBL_474154 |
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| Residue: | 376 |
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| Sequence: | MASYPCHQHASAFDQAARSRGHSNRRTALRPRRQQEATEVRLEQKMPTLLRVYIDGPHGM
GKTTTTQLLVALGSRDDIVYVPEPMTYWQVLGASETIANIYTTQHRLDQGEISAGDAAVV
MTSAQITMGMPYAVTDAVLAPHIGGEAGSSHAPPPALTLIFDRHPIAALLCYPAARYLMG
SMTPQAVLAFVALIPPTLPGTNIVLGALPEDRHIDRLAKRQRPGERLDLAMLAAIRRVYG
LLANTVRYLQGGGSWREDWGQLSGTAVPPQGAEPQSNAGPRPHIGDTLFTLFRAPELLAP
NGDLYNVFAWALDVLAKRLRPMHVFILDYDQSPAGCRDALLQLTSGMVQTHVTTPGSIPT
ICDLARTFAREMGEAN
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| BDBM50206500 |
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| n/a |
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| Name | BDBM50206500 |
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| Synonyms: | CHEMBL241166 | N2-octanoyl-9-(2'-O-octanoyl-beta-D-arabinofuranosyl)guanine |
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| Type | Small organic molecule |
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| Emp. Form. | C26H41N5O7 |
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| Mol. Mass. | 535.633 |
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| SMILES | CCCCCCCC(=O)Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](CO)[C@@H](O)[C@@H]1OC(=O)CCCCCCC |
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| Structure | 
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